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Lab Dept:
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Coagulation
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Test Name:
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FIBRINOGEN ANTIGEN AND CLAUSS
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General Information
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Lab Order Codes:
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FIBB
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Synonyms:
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Fibrinogen Immunologic Assay; Clauss Fibrinogen; Fibrinogen Activity
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CPT Codes:
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85384 – Fibrinogen; Activity
85385 – Fibrinogen; Antigen
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Test Includes:
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Immunologic antigen determination and clottable fibrinogen determination.
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Logistics
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Test Indications:
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Useful for identifying congenital afibrinogenemia, dysfibrinogenemia, disseminated intravascular coagulation (DIC), fibrinolytic activity and severe liver disease.
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Lab Testing Section:
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Coagulation - Sendouts
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Referred to:
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Fairview University Medical Center and Fairview forward to ARUP.
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Phone Numbers:
Minneapolis:
Saint Paul:
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612-813-6280
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651-220-6550
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Test Availability:
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Daily, 24 hours
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Turnaround Time:
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2 - 4 days, Activity performed daily, 24 hours; Antigen performed twice weekly
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Special Instructions:
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N/A
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Specimen
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Specimen Type:
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Whole blood
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Container:
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Light Blue top tube (Buffered Na Citrate 3.2%)
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Draw Volume:
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Minimum: 2.7 mL in a 3 mL tube
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Processed Volume:
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Specimen will be processed by the reference lab facility.
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Collection:
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Do Not use the first 2 mL’s of blood collected.
Patients with hematocrit levels >55% must have a special tube designed to adjust for the hematocrit. Contact lab for special tube.
Deliver specimen to lab immediately. Mix thoroughly by gentle inversion.
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Special Processing:
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Lab Staff: Do Not centrifuge. Send in original container. Specimen must arrive within 24 hours after collection. Protect from extreme temperatures during shipping.
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Patient Preparation:
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If the patient has a coagulation abnormality, apply direct pressure on the puncture site for 10 minutes; apply pressure bandage. Instruct the patient to leave the bandage on for 12 hours.
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Sample Rejection:
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Improper tube, Clotted samples, Underfilled tubes, Overfilled tubes, Mislabeled or unlabeled specimens
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Interpretive
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Reference Range:
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Activity:
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200 – 420 mg/dL
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Antigen:
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149 – 353 mg/dL
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Critical Values:
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Fibrinogen Activity: <100 mg/dL
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Limitations:
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N/A
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Methodology:
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Fibrinogen Activity: Electromagnetic clot detection
Fibrinogen Antigen: Radial immunodiffusion
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References:
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Fairview University Medical Center Web Page http://labguide.fairview.org/diagnostic.asp March 2005
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Update:
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3/18/2005: Change in Fibrinogen Antigen reference range, previously listed as 200 - 420 mg/dL.
5/24/2010: Tubing patient specimens is no longer prohibited.
3/28/2012: Updated Fibrinogen Ag ref range, now referred to ARUP. Updated Fibrinogen Activity Critical value.
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