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Lab Dept:
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Coagulation
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Test Name:
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PLASMINOGEN
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General Information
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Lab Order Codes:
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PLAG
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Synonyms:
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Plasminogen, Blood; Plasminogen, Chromogenic; Plasminogen Functional Assay; Plasminogen Immunologic Assay
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CPT Codes:
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85420 – Fibrinolytic factors; plasminogen, non-antigenic
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Test Includes:
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Plasminogen Activity
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Logistics
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Test Indications:
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Plasmin (the active form of Plasminogen) is part of the fibrinolytic system. It lyses fibrinogen and fibrin. Deficiencies are associated with arterial and venous thromboses. The Chromogenic (activity) assay detects the functionality of the molecule.
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Lab Testing Section:
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Coagulation - Sendouts
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Referred to:
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Fairview University Medical Center (Test# PLASCH)
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Phone Numbers:
Minneapolis:
Saint Paul:
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612-813-6280
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651-220-6550
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Test Availability:
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Daily, 24 hours
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Turnaround Time:
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2 - 7 days
One to two times per week. Note: This test is not analyzed on Saturday and Sunday.
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Special Instructions:
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N/A
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Specimen
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Specimen Type:
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Whole blood
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Container:
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Light Blue top (Buffered Na Citrate 3.2%) tube
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Draw Volume:
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2.7 mL blood in a 3 mL tube; Minimum: 1.8 mL in a 2 mL tube
Please reflect fill line on specimen tubes.
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Processed Volume:
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Specimen will be process by the reference lab facility.
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Collection:
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A clean venipuncture is essential. Do Not use the first 2 mL of blood collected.
Patient’s with hematocrits >55% must have a special tube made to adjust for the hematocrit: contact laboratory for special tube.
Mix thoroughly by gentle inversion. Deliver immediately to the laboratory.
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Special Processing:
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Lab Staff: Do Not centrifuge. Send in original Vacutainer® tube. Forward promptly at ambient temperature only. Must arrive within 24 hours.
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Patient Preparation:
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None
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Sample Rejection:
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Improper tube; clotted samples; underfilled tubes; overfilled tubes; mislabeled or unlabeled specimens
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Interpretive
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Reference Range:
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Age:
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Range (%):
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0 days:
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42 – 72%
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1 – 4 days:
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48 – 68%
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5 – 29 days:
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53 – 76%
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30 – 89 days:
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48 – 70%
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90 – 179 days:
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63 – 85%
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180 – 364 days:
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78 – 104%
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≥1 year:
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80 – 120%
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Critical Values:
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N/A
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Limitations:
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N/A
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Methodology:
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Chromogenic (Synthetic Substrate) Activity Assay
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References:
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Fairview University Diagnostic Laboratory Web Page June 2011
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Harmening DH (1997) Clinical Hematology and Fundamentals of Hemostasis
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Updates:
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5/21/2004: Test no longer includes Plasminogen antigen. The Chromogenic or activity portion is recommended. If there is a clinical reason for ordering the antigen, please contact the laboratory. References for the antigenic portion have been removed from this listing. Draw volume changed from 4.5 mL to 2.7 mL blood.
5/24/2010: Tubing patient specimens is no longer prohibited.
6/15/2011: Ref range update.
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