Clinics and Departments

Laboratory Services

Lab Dept:

Coagulation

Test Name:

FIBRINOGEN

General Information

Lab Order Codes:

FIB

Synonyms:

Clauss Fibrinogen; Plasma Fibrinogen

CPT Codes:

85384 – Fibrinogen; activity

Test Includes:

Fibrinogen level reported in mg/dL.

Logistics

Test Indications:

Used for identifying congenital afibrinogenemia, dysfibrinogenemia, disseminated intravascular coagulation (DIC), fibrinolytic activity and severe liver disease. This test is sensitive to functional fibrinogen, and insensitive to non-clottable fibrinogen and fibrin derivatives.

Lab Testing Sections:

Coagulation

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

2 hours

Special Instructions:

Deliver immediately to the laboratory; Indicate when specimen is drawn from a line or a heparin lock.

Specimen

Specimen Type:

Whole blood

Container:

Light Blue top tube (Buffered Na Citrate 3.2%)

Draw Volume:

1.8 mL or 2.7 mL blood

Processed Volume:

0.9 mL (Minimum: 0.5 mL) plasma

Collection:

● A clean venipuncture is essential, avoid foaming.
● Entire sample must be collected with single collection, pooling of sample is unacceptable.
● Capillary collection is unacceptable.
● Patient’s with a hematocrit level >55% must have a special tube made to adjust for the hematocrit; contact lab for a special tube.
● Mix thoroughly by gentle inversion. Deliver immediately to the laboratory at room temperature via courier or pneumatic tube.

Off campus collections:


● Must be tested within 4 hours.
● Do not refrigerate.
● If not received in our lab within 4 hours of collection, sample must be centrifuged and *platelet-poor plasma removed from cells and transferred to an aliquot tube. Freeze at -20C and deliver to the lab on dry ice within 2 weeks.
*Validation of your lab’s centrifuge for platelet poor plasma is required.

Special Processing:

Lab staff: Centrifuge in Stat Spin for 5 minutes or 10 minutes at 3000 rpm at room temperature. For primary tube testing, leave plasma on cells OR remove plasma and place in a 4 mL plastic cup; allow for 100 mL of deadspace.

Test within:
● Four (4) hours when stored in the capped tube above the packed cells 18 to 24C.
● Four (4) hours as plasma that has been separated from cells by centrifugation when stored 2 to 8C or 18 to 24C.
● Two (2) weeks when stored -20C.
● Six (6) months when stored -70C (rapidly frozen).
● Plasma must be frozen if testing cannot be completed within four (4) hours.
● Frozen plasmas are thawed at 37C for three (3) minutes, test immediately.

Patient Preparation:

None

Sample Rejection:

Improper tube; clotted samples; overfilled tubes; underfilled tubes; mislabeled or unlabeled specimens

Interpretive

Reference Range:

200 – 420 mg/dL

Critical Values:

<100 mg/dL

Limitations:

N/A

Methodology:

Electromagnetic clot detection

References:

Harmening DH (1997) Clinical Hematology and Fundamentals of Hemostasis

Updates:

2/17/2005: Critical value previously listed as <100 mg/dL.
3/27/2012: Updated reference range, critical value and method.
9/15/2014: Off campus collection info added.



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