Clinics and Departments

Laboratory Services

Lab Dept:

Coagulation

Test Name:

D DIMER

General Information

Lab Order Codes:

DDI

Synonyms:

D-dimer

CPT Codes:

85379 – Fibrin degradation products, D-dimer; quantitative

Test Includes:

Fibrin D-Dimer reported in mg/L FEU.

Logistics

Test Indications:

Useful for the detection of deep vein thrombosis, evaluation of disseminated intravascular coagulation (DIC), acute myocardial infarction, unstable angina, and in following a leukemia patient’s chemotherapy.

Lab Testing Sections:

Coagulation

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

2 hours

Special Instructions:

None

Specimen

Specimen Type:

Whole blood

Container:

Light Blue top tube (Buffered Na Citrate 3.2%)

Draw Volume:

1.8 mL for 3 coagulation tests or less
2.7 mL for 4 coagulation tests or if factor assay is ordered

Processed Volume:

Minimum: 0.1 mL plasma

Collection:

● A clean venipuncture is essential.
● Patient’s with hematocrit levels >55% must have a special tube made to adjust for the hematocrit; contact laboratory for special tube.
● Deliver immediately to the laboratory.
● Refrigerate specimen if there is a delay in transport of 30 minutes or more.

Special Processing:

Centrifuge immediately upon arrival in laboratory.

Patient Preparation:

None

Sample Rejection:

Improper tube; clotted sample; underfilled tube; mislabeled or unlabeled specimens

Interpretive

Reference Range:

A clinical cut-off of 0.5 mg/L FEU when used along with a low clinical pretest probability assessment model has been established to exclude DVT/PE.

Interpretation: Results of D-Dimer should always be interpreted in conjunction with the patient’s medical history, clinical presentation and other findings. Clinical diagnosis should not be based on the results of D-Dimer alone.

Critical Values:

N/A

Limitations:

Elevated D-dimer levels are not specific for the presence of DIC or of deep vein thrombosis. False-positive or false-negative results may occur when attempting to confirm a diagnosis of DIC.

Methodology:

Immunoturbidometric (optical)

References:

Wayne, PA (January 2008).Clinical Laboratory Standards Institute, Collection, Transport and Processing Blood Specimens for Testing Plasma-Based Coagulation Assays: Approved Guideline, 5th Edition,CLSI Publication H21-A5, An Algorithmic Approach to Hemostasis Testing, Kottke-Marchant,CAP Press

Updates:

7/16/2012: Method update. Previously a screening test; Monoclonal Antibodies Attached to Latex Particles
CPT update, previously listed as 85378.



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