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Lab Dept:
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Coagulation
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Test Name:
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D DIMER
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General Information
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Lab Order Codes:
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DDI
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Synonyms:
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D-dimer
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CPT Codes:
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85379 – Fibrin degradation products, D-dimer; quantitative
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Test Includes:
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Fibrin D-Dimer reported in mg/L FEU.
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Logistics
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Test Indications:
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Useful for the detection of deep vein thrombosis, evaluation of disseminated intravascular coagulation (DIC), acute myocardial infarction, unstable angina, and in following a leukemia patient’s chemotherapy.
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Lab Testing Sections:
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Coagulation
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Phone Numbers:
Minneapolis:
Saint Paul:
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612-813-6280
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651-220-6550
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Test Availability:
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Daily, 24 hours
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Turnaround Time:
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2 hours
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Special Instructions:
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None
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Specimen
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Specimen Type:
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Whole blood
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Container:
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Light Blue top tube (Buffered Na Citrate 3.2%)
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Draw Volume:
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1.8 mL for 3 coagulation tests or less
2.7 mL for 4 coagulation tests or if factor assay is ordered
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Processed Volume:
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Minimum: 0.1 mL plasma
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Collection:
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● A clean venipuncture is essential.
● Patient’s with hematocrit levels >55% must have a special tube made to adjust for the hematocrit; contact laboratory for special tube.
● Deliver immediately to the laboratory.
● Refrigerate specimen if there is a delay in transport of 30 minutes or more.
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Special Processing:
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Centrifuge immediately upon arrival in laboratory.
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Patient Preparation:
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None
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Sample Rejection:
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Improper tube; clotted sample; underfilled tube; mislabeled or unlabeled specimens
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Interpretive
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Reference Range:
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A clinical cut-off of 0.5 mg/L FEU when used along with a low clinical pretest probability assessment model has been established to exclude DVT/PE.
Interpretation: Results of D-Dimer should always be interpreted in conjunction with the patient’s medical history, clinical presentation and other findings. Clinical diagnosis should not be based on the results of D-Dimer alone.
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Critical Values:
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N/A
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Limitations:
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Elevated D-dimer levels are not specific for the presence of DIC or of deep vein thrombosis. False-positive or false-negative results may occur when attempting to confirm a diagnosis of DIC.
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Methodology:
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Immunoturbidometric (optical)
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References:
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Wayne, PA (January 2008). Clinical Laboratory Standards Institute, Collection, Transport and Processing Blood Specimens for Testing Plasma-Based Coagulation Assays: Approved Guideline, 5th Edition,CLSI Publication H21-A5, An Algorithmic Approach to Hemostasis Testing, Kottke-Marchant, CAP Press
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Updates:
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7/16/2012: Method update. Previously a screening test; Monoclonal Antibodies Attached to Latex Particles
CPT update, previously listed as 85378.
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