Clinics and Departments

Laboratory Services

Lab Dept:

Coagulation

Test Name:

ALPHA-2 ANTIPLASMIN CHROMOGENIC (FAIRIVEW UNIVERSITY)

General Information

Lab Order Codes:

A2AC

Synonyms:

Alpha 2 Antiplasmin Activity; Antiplasmin Functional Assay

CPT Codes:

85410 – Alpha-2 antiplasmin

Test Includes:

Antiplasmin activity level reported as a %.

Logistics

Test Indications:

Alpha-2 Antiplasmin is a specific inhibitor of Plasmin. A deficiency may result in a bleeding tendency. Homozygous deficiency may cause severe bleeding. Elevated levels may cause thrombosis.

Lab Testing Sections:

Coagulation - Sendouts

Referred to:

Fairview University Medical Center (Forward to ARUP, Fairview/Altas test: APCH)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours. Test is performed as needed.

Turnaround Time:

Within 7 days

Special Instructions:

Indicate when specimen is drawn from a line or a heparin lock. Deliver immediately to the laboratory.

Specimen

Specimen Type:

Whole blood

Container:

Light Blue top (Buffered Na Citrate 3.2%) tube

Draw Volume:

2.7 mL blood in a 3 mL tube (Minimum: 1.8 mL in a 2 mL tube).

Processed Volume:

Specimens will be processed at reference lab facility if received within 4 hours of collection. Otherwise, specimens need to be processed at referring facility and provide minimum of two 0.5 mL specimens frozen at -70. Follow directions below under Special Processing.

Collection:

Do Not use the first 2 mL’s of blood collected.

Patients with hematocrit levels of >55% must have a special tube made to adjust for the hematocrit, contact laboratory for special tube.

Fill tube completely. Mix thoroughly by gentle inversion.

If the patient has a coagulation abnormality, apply direct pressure to the puncture site for 10 minutes; apply a pressure dressing. Instruct the patient to leave the bandage on for 12 hours.

Special Processing:

Lab Staff: Do Not centrifuge. Do Not freeze. Send to reference lab in original Vacutainer® at room temperature if within 4 hours of collection. Forward promptly.

If specimen is >4 hours old prior to shipment, process specimen as follows:
Spin sample collected in blue top tube(s) for 5 minutes on the Stat Spin centrifuge, remove plasma and transfer to a 4 mL BCS sample cup(s), spin remaining plasma again for 5 minutes in the Stat Spin Centrifuge. Transfer plasma into two labeled 10x75 mL plastic tubes with a minimum of 0.5 mL in each. Freeze at -70 and send specimens on dry ice to Fairview University.

Patient Preparation:

None

Sample Rejection:

Improper tube; clotted samples; underfilled tubes; overfilled tubes; mislabeled or unlabeled specimens

Interpretive

Reference Range:

Age:

Range (%):

1 – 4 days

55 – 115%

5 – 29 days

70 – 130%

30 – 89 days

76 – 124%

90 – 179 days

76 – 140%

180 – 364 days

83 – 139%

1 – 5 years

93 – 117%

6 years

89 – 110%

7 – 9 years

88 – 147%

10 – 11 years

90 – 144%

12 – 13 years

87 – 142%

14 – 15 years

83 – 136%

16 – 17 years

77 – 134%

18 years and older

82 – 133%

Critical Values:

N/A

Limitations:

N/A

Methodology:

Chromogenic (synthetic substrate) activity assay

References:

Fairview University Web Page February 2014

Harmening DH (1997) Clinical Hematology and Fundamentals of Hemostasis

Updates:

5/25/2010: Tubing patient specimens is no longer prohibited.
2/25/2014: Fairview specimen processing update.



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