Clinics and Departments

Laboratory Services

Lab Dept:

Hematology

Test Name:

HAPTOGLOBIN

General Information

Lab Order Codes:

HAPT

Synonyms:

N/A

CPT Codes:

83010 – Haptoglobin; quantitative

Test Includes:

Total haptoglobin level reported in mg/dL.

Logistics

Test Indications:

A decreased serum haptoglobin level is a very sensitive test of both intravascular and extravascular hemolysis, and reflects the rapid clearance by the reticuloendothelial system of a complex formed between liberated hemoglobin and circulatory haptoglobin. Low levels may also occur in hepatocellular disease, reflecting decreased synthesis by the liver, and that some patients may have a genetically determined deficiency of haptoglobin. Increased synthesis of haptoglobin in acute inflammatory states or malignancy may also mask depletion of serum haptoglobin due to hemolysis.

Lab Testing Sections:

Hematology - Sendouts

Referred to:

Mayo Medical Laboratories (Test: HAPT/9168)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

1 – 2 days, test set up Monday - Saturday

Special Instructions:

N/A

Specimen

Specimen Type:

Blood

Container:

Red top tube

Draw Volume:

3 mL (Minimum: 1.5 mL) blood

Processed Volume:

1 mL (Minimum: 0.5 mL) serum

Collection:

Routine venipuncture

Special Processing:

Lab Staff: Centrifuge specimen, remove serum aliquot into a screw capped round bottom plastic vial. Store and ship at refrigerated temperatures. Forward promptly.

Patient Preparation:

None

Sample Rejection:

Specimens other than serum; mislabeled or unlabeled specimens

Interpretive

Reference Range:

30 – 200 mg/dL

Critical Values:

N/A

Limitations:

Low haptoglobin is normal for the first 3-6 months of life. Haptoglobin is an acute-phase reactant and increases with inflammation or tissue necrosis. Test measures total haptoglobin.

Methodology:

Nephelometry

References:

Mayo Medical Laboratories Web Page September 2012

Harmening DH (1997) Clinical Hematology and Fundamentals of Hemostasis, 3rd ed

Updates:

2/26/2004: Test moved from Fairview to Mayo Medical Laboratories. Note change in reference range. Lower end previously 15 mg/dL.



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