Clinics and Departments

Laboratory Services

Lab Dept:

Hematology

Test Name:

UNSTABLE HEMOGLOBIN

General Information

Lab Order Codes:

UHG

Synonyms:

Hemoglobin, Unstable, Blood; Test for congenital Heinz Body Hemolytic Anemia; Hgb Heat Sensitivity; Heat Stability Test; Isopropanol Stability Test; RBC Heat Stability Test

CPT Codes:

83068 - Hemoglobin; unstable, screen

Test Includes:

Unstable hemoglobin reported as Normal (stable) or Abnormal (unstable).

Logistics

Test Indications:

Determine the presence of unstable hemoglobins, most of which are not identified by routine hemoglobin electrophoresis, although subtle indications of an abnormality may be observed. Work-up of congenital hemolytic anemias

Lab Testing Sections:

Hematology - Sendouts

Referred to:

Mayo Medical Laboratories (MML Test# UNHB/9095)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

1 – 4 days

Special Instructions:

N/A

Specimen

Specimen Type:

Whole blood

Container:

Lavender top (EDTA) tube
Alternate: Yellow (ACD) or Green top tubes

Draw Volume:

4 mL blood

Processed Volume:

Same as Draw Volume

Collection:

Routine venipuncture. Mix specimen well by gentle inversion.

Special Processing:

Lab Staff: Do not centrifuge. Specimen should remain in original collection container. Store and ship at refrigerated temperatures. Forward promptly.

Patient Preparation:

None

Sample Rejection:

Clotted, frozen, mislabeled or unlabeled specimens; specimens >7 days old; specimens other than whole blood

Interpretive

Reference Range:

Normal (reported as normal [stable] or abnormal [unstable])

Interpretation: An abnormal or unstable result is indicative of a hemoglobin variant present. Other confirmatory tests should be performed to identify the hemoglobinopathy.

Critical Values:

N/A

Limitations:

False-positive results will be obtained in blood specimen that contain >5% fetal hemoglobin or in specimens that are received more than one week old.

Methodology:

Isopropanol Solubility

References:

Mayo Medical Laboratories Web Page October 2013

Harmening DH (1997) Clinical Hematology and Fundamentals of Hemostasis, 3rd ed

Updates:

10/2/13: Specimen volume change, previously listed as 2 mL.



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