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Lab Dept:
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Hematology
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Test Name:
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UNSTABLE HEMOGLOBIN
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General Information
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Lab Order Codes:
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UHG
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Synonyms:
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Hemoglobin, Unstable, Blood; Test for congenital Heinz Body Hemolytic Anemia; Hgb Heat Sensitivity; Heat Stability Test; Isopropanol Stability Test; RBC Heat Stability Test
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CPT Codes:
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83068 - Hemoglobin; unstable, screen
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Test Includes:
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Unstable hemoglobin reported as Normal (stable) or Abnormal (unstable).
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Logistics
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Test Indications:
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Determine the presence of unstable hemoglobins, most of which are not identified by routine hemoglobin electrophoresis, although subtle indications of an abnormality may be observed. Work-up of congenital hemolytic anemias
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Lab Testing Sections:
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Hematology - Sendouts
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Referred to:
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Mayo Medical Laboratories (MML Test# UNHB/9095)
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Phone Numbers:
Minneapolis:
Saint Paul:
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612-813-6280
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651-220-6550
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Test Availability:
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Daily, 24 hours
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Turnaround Time:
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1 – 4 days
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Special Instructions:
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N/A
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Specimen
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Specimen Type:
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Whole blood
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Container:
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Lavender top (EDTA) tube
Alternate: Yellow (ACD) or Green top tubes
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Draw Volume:
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2 mL (Minimum: 1 mL) blood
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Processed Volume:
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Same as Draw Volume
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Collection:
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Routine venipuncture. Mix specimen well by gentle inversion.
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Special Processing:
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Lab Staff: Do not centrifuge. Specimen should remain in original collection container. Store and ship at refrigerated temperatures. Forward promptly.
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Patient Preparation:
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None
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Sample Rejection:
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Clotted, frozen, mislabeled or unlabeled specimens; specimens >7 days old; specimens other than whole blood
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Interpretive
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Reference Range:
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Normal (reported as normal [stable] or abnormal [unstable])
Interpretation: An abnormal or unstable result is indicative of a hemoglobin variant present. Other confirmatory tests should be performed to identify the hemoglobinopathy.
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Critical Values:
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N/A
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Limitations:
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False-positive results will be obtained in blood specimen that contain >5% fetal hemoglobin or in specimens that are received more than one week old.
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Methodology:
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Isopropanol Solubility
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References:
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Mayo Medical Laboratories Web Page September 2012
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Harmening DH (1997) Clinical Hematology and Fundamentals of Hemostasis, 3rd ed
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