Clinics and Departments

Laboratory Services

Lab Dept:

Microbiology/Virology

Test Name:

CMV BY PCR, BLOOD

General Information

Lab Order Codes:

CMVQU

Synonyms:

Cytomegalovirus PCR

CPT Codes:

87497 - Infectious agent detection by nucleic acid (DNA or RNA); cytomegalovirus amplified probe technique

Test Includes:

CMV detection by PCR. This test does not include CMV Culture. Refer to Viral Culture.

Logistics

Test Indications:

Early detection of CMV viremia. Predicting CMV disease and response to viral therapy.

Lab Testing Sections:

Microbiology/Serology - Sendouts

Referred to:

Mayo Medical Laboratories (Test: CMVQU)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

1 – 3 days, test set-up Monday - Saturday

Special Instructions:

N/A

Specimen

Specimen Type:

Blood

Container:

Lavender top (EDTA) tube

Draw Volume:

7.5 mL (Minimum: 2.5 mL) blood

Processed Volume:

3 mL (Minimum: 1 mL) plasma

Collection:

Routine venipuncture, invert gently to mix.

Special Processing:

Lab Staff: Centrifuge specimen, remove plasma aliquot (within 6 hours of collection) into a screw-capped plastic vial. Store and ship at frozen temperatures. Forward promptly.

Patient Preparation:

None

Sample Rejection:

Specimens other than plasma; mislabeled specimens or unlabeled specimens

Interpretive

Reference Range:

Undetected

A positive test result indicates presence of CMV DNA; a quantitative value (IU/mL) is reported.

A result of “Undetected” does not rule out the presence of CMV DNA. This test should not be used as the only criterion to form a clinical conclusion, instead, results should be correlated with other test results, patient symptoms, and clinical presentation.

Limitations:

A result of “Undetected” does not necessarily indicate the absence of CMV infection. False-positive results also may be due to suppression of virus replication to levels below the detection threshold, or to inhibitory substances that may be present in the specimens.

Inadequate specimen collection or storage may invalidate test results.

Methodology:

Real-Time Reverse Transcription-Polymerase Chain Reaction (RT-PCR)

Additional Information:

CMV may be present in the blood in healthy seropositive individuals at very low levels. CMV serology may confirm current infection.

References:

Mayo Medical Laboratories Web June 2013

Updates:

3/18/2004: Test moved from Eastern Virginia Medical School Department of Pathology to Mayo Medical Laboratories.
6/3/2013: Method change, previously listed as Real-Time PCR/DNA Probe Hybridization



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