Clinics and Departments

Laboratory Services

Lab Dept:

Other Fluids

Test Name:

IGG INDEX, CSF

General Information

Lab Order Codes:

IGGI

Synonyms:

Cerebrospinal Fluid (CSF) IgG Index

CPT Codes:

82040 – albumin, serum
82042 – albumin, urine or other source, quantitative
82784 x2 – gammaglobulin; IgG, each

Test Includes:

IgG synthesis rate CSF. Both CSF and serum are required for this test.

Logistics

Test Indications:

The CSF index is useful in the diagnosis of individuals with multiple sclerosis.

The index is independent of activity of the demyelinating process

Lab Testing Sections:

Chemistry - Sendouts

Referred to:

Mayo Medical Laboratories (Test: 8009/SFIN)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

1 - 3 days, test set up Monday - Saturday

Special Instructions:

N/A

Specimen

Specimen Type:

Both serum and spinal fluid are required for this test and must be obtained within 1 week of each other

Container:

Blood: Red top tube

CSF: Screw capped, sterile vial

Draw Volume:

3 mL blood

1 mL CSF

Processed Volume:

1 mL (Minimum: 0.5 mL) serum and 1 mL (Minimum: 0.5 mL) spinal fluid

Collection:

Routine venipuncture and spinal fluid collection

Special Processing:

Lab Staff: Centrifuge blood specimen, remove serum aliquot and refrigerate in a plastic screw-top vial. Aliquot CSF into a plastic screw-top vial and refrigerate. Label specimen source appropriately on each tube. Send at refrigerated temperatures. Forward promptly.

Patient Preparation:

None

Sample Rejection:

N/A

Interpretive

Reference Range:

CSF index:

0.00 - 0.85

CSF IgG:

0.00 - 8.1 mg/dL

CSF albumin:

0.0 - 27.0 mg/dL

Serum IgG:

0 – 4 months

100 – 334 mg/dL

5 – 8 months

164 – 588 mg/dL

9 – 14 months

246 – 904 mg/dL

15 – 23 months

313 – 1170 mg/dL

2 – 3 years

295 – 1156 mg/dL

4 – 6 years

386 – 1470 mg/dL

7 – 9 years

462 – 1682 mg/dL

10 – 12 years

503 – 1719 mg/dL

13 – 15 years

509– 1580 mg/dL

16 – 17 years

487 – 1327 mg/dL

>or = 18 years

767 – 1590 mg/dL

Serum albumin:

3200 - 4800 mg/dL

CSF IgG/albumin:

≤0.21 mg/dL

Serum IgG/albumin:

≤0.4 mg/dL

CSF IgG synthesis rate:

≤12 mg/24 hours

Critical Values:

N/A

Limitations:

The CSF index can be elevated in other inflammatory demyelinating diseases such as neurosyphilis , acute inflammatory polyradiculoneuropathy, and subacute slerosing panencepahlaitis.

Methodology:

Nephelometry

References:

Mayo Medical Laboratories Web Page June 2013



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