Clinics and Departments

Laboratory Services

Lab Dept:

Other Fluids

Test Name:

AFP, CSF

General Information

Lab Order Codes:

AFPC

Synonyms:

Alpha-Fetoprotein (AFP), Spinal fluid

CPT Codes:

86316 – Immunoassay for tumor antigen; other antigen, quantitative

Test Includes:

AFP CSF concentration reported in ng/mL.

Logistics

Test Indications:

Useful as an adjunct in the diagnosis of CNS germinomas and meningoceal carcinomatosis. Evaluating germ-cell tumors, including testicular cancer metastatic to the CNS in conjunction with beta-hCG measurement. An adjunct in distinguishing between suprasellar dysgerminomas and craniopharyngiomas. A supplement to cerebrospinal fluid cytologic analysis.

Lab Testing Sections:

Chemistry - Sendouts

Referred to:

Mayo Medical Laboratories (MML Test: 8876/AFPSF)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

1 - 3 day, test set up Monday - Saturday

Special Instructions:

N/A

Specimen

Specimen Type:

Spinal fluid

Container:

Screw capped, sterile vial

Draw Volume:

0.5 mL (Minimum:0.5 mL) CSF

Processed Volume:

Same as Draw Volume

Collection:

Routine spinal fluid collection

Special Processing:

Lab Staff: Freeze specimen in plastic vial and send frozen.

Patient Preparation:

None

Sample Rejection:

Mislabeled or unlabeled specimens; warm specimens

Interpretive

Reference Range:

<1.5 ng/mL

Reference range for newborns is not available.

Critical Values:

N/A

Limitations:

Malignancy may occur without elevation of AFP concentration. AFP elevation occurs in approximately 70% of CNS germinomas. Measurement of beta-hCG is recommended to improve sensitivity of detection.

Methodology:

Two-site Immunoenzymatic (Sandwich)

Contraindications:

N/A

References:

Mayo Medical Web Page June 2013

For serum ranges, see literature references: Ped Res 15:50-52(1981); Scand J Immunol 8(Supplement 8): 235-238



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