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Lab Dept:
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Fanconi Anemia
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Test Name:
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ANATOMIC PATHOLOGY
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General Information
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Lab Order Codes:
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FANC
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Synonyms:
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Fanconi Mutagen Sensitivity Study; DEB Test; Mutagen Stress Test; Mitomycin C Test
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CPT Codes:
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88230 – Tissue culture for non-neoplastic disorders; lymphocyte
88249 – Chromosome analysis for breakage syndromes; score 100 cells, clastogen stress
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Test Includes:
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Diagnostic report
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Logistics
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Test Indications:
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Useful for the differential diagnosis between idiopathic aplastic anemia and Fanconi anemia. After treatment with similar doses of bifunctional alkylating agents such as Diepoxybutane (DEB) or Mitomycin C (MMC). Fanconi anemia patients will typically show a greater than 50-fold increase in rates of chromosome breakage compared to concurrent controls or other aplastic anemia patients.
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Lab Testing Sections:
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Anatomic Pathology - Sendouts
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Referred to:
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Fairview University Medical Center
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Phone Numbers:
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MIN Lab: 612-813-6280
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STP Lab: 651-220-6550
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Test Availability:
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Daily, 24 hours
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Turnaround Time:
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Performed daily; results are reported within 7-14 days
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Special Instructions:
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Please provide diagnosis (or reason for referral), clinical status, information regarding medication or transfusions. Obtain Green Sodium Heparin (no gel) tube from the laboratory.
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Specimen
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Specimen Type:
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Whole blood
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Container:
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Green top (Sodium Heparin, no gel) tube. Obtain from laboratory.
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Draw Volume:
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10 mL preferred (Minimum: 5 mL) whole blood
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Processed Volume:
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Same as Draw Volume
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Collection:
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Routine venipuncture
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Special Processing:
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Lab Staff: Store and ship specimen at room temperature. Do Not centrifuge or freeze. Specimen must arrive at reference laboratory within 24 hours.
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Patient Preparation:
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None
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Sample Rejection:
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Clotted specimen; mislabeled or unlabeled specimen
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Interpretive
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Reference Range:
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Interpretive report
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Critical Values:
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N/A
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Limitations:
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N/A
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Methodology:
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Determined by laboratory director based on clinical information
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References:
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Fairview University Web Page January 2012
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Updates:
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2/5/2013: CPT update
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