Clinics and Departments

Laboratory Services

Lab Dept:

Anatomic Pathology

Test Name:

COMPARATIVE GENOMIC HYBRIDIZATION (CGH)

General Information

Lab Order Codes:

CGH: Full assay (full charge)
CGHL: Limited assay, known pathologic mutation (limited charge)
CHGV: Variant of unknown significance (no charge)

Correct assay order should be based on clinical findings.

Synonyms:

Comparative Genomic Hybridization, Microarray; aCGH

CPT Codes:

CGH:
81228 – Cytogenomic constitutional microarray analysis

CGHL:
88230 – Tissue culture for non-neoplastic disorders; lymphocyte
88271 – Molecular cytogenetics; DNA probe, each
88275 – Molecular cyotgenetics; interphase in situ hybridization, analyze 100-300 cells

Test Includes:

For characterization of abnormalities detected by G-banding.

Logistics

Test Indications:

FISH for detection of small duplications and deletions in patients with normal G-banded karyotypes.

Lab Testing Sections:

Anatomic Pathology - Sendouts

Referred to:

Fairview University Medical Center – Cytogenetics Lab (CYHOLD-CGH)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

Performed Monday-Friday. Results are reported within 28 days.

Special Instructions:

Please see Container and Draw Volume

Specimen

Specimen Type:

Whole Blood

Container:

Green (sodium heparin, no gel) AND Lavender (EDTA) top tubes
Both tubes are required.

Note: A Yellow (ACD) tube can be substituted for the Lavender top tube.

Draw Volume:

20 mL (10 mL per tube) (Minimum: 10 mL [5 mL per tube]) blood

Note: 1-3 mL per tube Minimum for infants and children, with 3 mL strongly preferred

Processed Volume:

Same as Draw Volume

Collection:

Routine Venipuncture

Special Processing:

Lab Staff: Do Not Centrifuge. Specimen should remain in the original collection container. Store and ship at room temperature. Order in Atlas for communication to Fairview.

Patient Preparation:

None

Sample Rejection:

Clotted or frozen sample; mislabeled or unlabeled specimens

Interpretive

Reference Range:

Interpretive report

Critical Values:

N/A

Limitations:

Post-natal studies only.

Methodology:

FISH - Fluorescence in-situ hybridization

References:

Fairview Diagnostic Laboratories – Cytogenetics Lab http://labguide.fairview.org/showTest.asp?testid=4208 May 2008

Updates:

4/7/2008: Specimen requirements changed to include both Sodium Heparin and EDTA/ACD blood.
5/2/2008: CPT change from 88385x2 to 88271x2
5/20/2008: Addition of Minimum draw info for infants and children.
9/29/2008: CPT and price update from Fairview.
7/22/2010: CPT update
2/15/2011: CPT update
2/4/2013: CPT update



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