Clinics and Departments

Laboratory Services

Lab Dept:

Serology

Test Name:

HEPATITIS Bc ANTIBODY (ANTI-HBc)

General Information

Lab Order Codes:

HBC

Synonyms:

Hepatitis B Core Viral Antibody; Hepatitis B Core IgG/IgM Antibody; Anti-HBC; HBcAb

CPT Codes:

86704 – Hepatitis B core antibody (HbcAb); total

Test Includes:

Hepatitis Bc Total (IgG and IgM combined) Antibody level.

Logistics

Test Indications:

Differentiation between acute and chronic hepatitis B infection. Diagnosis of acute hepatitis B infection in the “core window” when HbsAg and anti HBs are negative. Discriminating between HbsAg-positive patients (carriers) whose acute hepatitis is due to HBV infection and those whose acute hepatitis is due to other causes. Because low titer of IgM anti-Hbc can be either absent or present in chronic HBV carriers, IgM anti-HBc assessment is not usually considered useful in diagnosing chronic active or chronic persistent hepatitis B. Not useful for demonstration of immunity to or recovery from hepatitis B viral infection.

Lab Testing Sections:

Serology - Sendouts

Referred to:

Mayo Medical Laboratories (Test# 8347)

Phone Numbers:

Minneapolis:

Saint Paul:

 

612-813-6280

651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

1 - 2 days, test performed daily.

Special Instructions:

This test is not offered as a screening or confirmatory test for blood donor specimens.

Specimen

Specimen Type:

Whole blood

Container:

Red top tube

Alternate tube: Lavender top (EDTA) tube

Draw Volume:

3.0 mL blood

Processed Volume:

1.0 mL (Minimum: 0.5 mL) serum/plasma

Collection:

Routine venipuncture

Special Processing:

Lab Staff: Centrifuge specimen, remove serum/plasma from clot within 24 hours. Place serum/plasma aliquot into a screw-capped round bottom plastic vial. Store and ship at frozen temperatures. Forward promptly.

Patient Preparation:

None

Sample Rejection:

Specimens other than serum or EDTA plasma, hemolysis, lipemia

Interpretive

Reference Range:

Negative (reported as positive or negative)
Interpretation depends on clinical setting.

Critical Values:

N/A

Limitations:

A weakly positive anti-HBc test result unaccompanied by other hepatitis B serological markers, elevated liver enzymes, or a history of risk factors may be a false-positive result.

Performance characteristics have not been established for the following specimen characteristics: lipemia, hemolysis, specimens containing particulate matter.

Methodology:

Chemiluminescence Immunoassay (CIA)

Contraindications:

N/A

References:

Mayo Medical Laboratories Web Page http://www.mayoreferenceservices.org/mrs/mml/index.asp August 2005

Updates:

4/6/2004: Test moved from Memorial Blood Center of Minneapolis to Mayo Medical Laboratories. Test is now an automatic reflex to the IgM specific Anti-HBc.

3/15/2005: Updated test method for Hepatitis Bc IgM antibody. Previously listed as Microparticle Enzyme Immunoassay (MEIA).

8/10/2005: Test no longer reflexes to Hepatitis B Core IgM Specific test when Hepatitis Bc Ab is positive. The IgM specific test must be ordered separately if desiried. Note: Change in methodology previously listed as Enzyme Immunoassay (EIA).



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