Clinics and Departments

Laboratory Services

Lab Dept:

Serology

Test Name:

HEPATITIS B CORE IgM ANTIBODY (ANTI-HBc IGM)

General Information

Lab Order Codes:

HBCM

Synonyms:

Hepatitis B Core IgM Specific; Hepatitis Bc Antibody; Hepatitis B Core Antibody IgM Fraction

CPT Codes:

86705 – Hepatitis B core antibody; IgM antibody

Test Includes:

Hepatitis B Core IgM Specific Antibody reported as positive or negative.

Logistics

Test Indications:

Diagnosis of acute hepatitis B infection. Identifying acute hepatitis B virus infection in the “core window” period, when HbsAg and anti-HBs are negative. Differentiation between acute and chronic hepatitis B infection when used in conjunction with anti-HBc IgG and IgM.

Lab Testing Sections:

Serology - Sendouts

Referred to:

Mayo Medical Laboratories (MML Test# HBIM/9015)

Phone Numbers:

Minneapolis:

Saint Paul:

 

612-813-6280

651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

1 - 2 days; test setup daily

Special Instructions:

N/A

Specimen

Specimen Type:

Blood

Container:

Red top tube

Draw Volume:

3 mL (Minimum: 1.5 mL) blood

Processed Volume:

1 mL (Minimum: 0.5 mL) serum

Collection:

Routine venipuncture

Special Processing:

Lab Staff: Allow specimen to clot, centrifuge and remove serum within 24 hours of collection. Remove serum aliquot into a screw-capped round bottom plastic vial. Store and ship at frozen temperatures. Forward promptly.

Patient Preparation:

None

Sample Rejection:

Gross hemolysis; warm specimens; gross lipemia; grossly icteric’ mislabeled or unlabeled specimens

Interpretive

Reference Range:

Negative

Note: A positive result indicates recent acute hepatitis B infection. A negative result suggests lack of recent exposure to the virus.

Critical Values:

N/A

Limitations:

Performance characteristics have not been established for the following specimen characteristics:

Grossly icteric: Total bilirubin level of >20 mg/dL
Grossly lipemic: Triolein level of >3000 mg/dL
Grossly hemolyzed: Hemoglobin level of >500 mg/dL
Containing particulate matter
Cadaveric specimens

Methodology:

Chemiluminescence Immunoassay

References:

Mayo Medical Laboratories Web Page September 2012

Updates:

4/6/2004: Test moved from Memoral Blood Center of Minneapolis to Mayo Medical Laboratories.
3/8/2005: Methodology previously listed as Enzyme Immunoassay.
9/27/2010: Specimen volume updates.



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