Clinics and Departments

Laboratory Services

Lab Dept:

Serology

Test Name:

CENTROMERE ANTIBODIES, IGG

General Information

Lab Order Codes:

CENA

Synonyms:

Anti-Centromere Antibodies; ACA; CREST

CPT Codes:

83520 – Immunoassay for analyte other than infectious agent antibody or infectious agent antigen; quantitative, not otherwise specified

Test Includes:

Centromere antibody reported as negative or positive.

Logistics

Test Indications:

Evaluating patients with clinical signs and symptoms compatible with systemic sclerosis including skin involvement, Raynaud’s phenomenon, and arthralgias.

Lab Testing Sections:

Serology - Sendouts

Referred to:

Mayo Medical Laboratories (MML Test: 9278/CMA)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

1 – 3 days, test set up Monday through Saturday

Special Instructions:

N/A

Specimen

Specimen Type:

Blood

Container:

Red top tube

Draw Volume:

1.5 mL (Minumum: 1.1 mL) blood

Processed Volume:

0.5 mL (Minimum: 0.35 mL) serum

Collection:

Routine venipuncture

Special Processing:

Lab Staff: Centrifuge specimen, remove serum aliquot into screw-capped round bottom plastic vial. Store and ship refrigerated. Forward promptly.

Patient Preparation:

None

Sample Rejection:

Specimens other than serum, warm specimens, gross hemolysis, gross lipemia, mislabeled or unlabeled specimens

Interpretive

Reference Range:

All Ages:

<1.0 U

Negative

≥1.0 U

Positive

Interpretation: In various reported clinical studies, Anti-Centromere Antibodies occur in 50-96% of patients with CREST syndrome.

A positive test for Centromere Antibodies is strongly associated with CREST syndrome. The presence of detectable levels of centromere antibodies may antedate the appearance of diagnostic clinical features of CREST syndrome, in some cases by several years.

Critical Values:

N/A

Limitations:

Centromere antibodies have also been described in some patients with primary biliary cirrhosis, and may occur in patients with rheumatoid arthritis or lupus erythematosus.

Methodology:

Multiplex Flow Immunoassay

References:

Mayo Medical Laboratory Web Page July 2013

Updates:

1/6/2006: CPT 2006 changes
11/1/2007: Addition of units and numeric reporting along with negative and positive results. Change in method, previously listed as EIA. CPT update, previously listed as 83516.
4/11/2011: CPT change from 88184 to 83520.



  Lab Test Directory
    Chemistry
    Coagulation
    Flow/Immunology
    Hematology
    Microbiology/ Virology
    Other Fluids
    Pathology
    Serology
    Transfusion Services
    Urine/Stool

  Search Lab Test Directory
    List All Documents

  Lab Staff

  E-mail Lab Services