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Lab Dept:
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Serology
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Test Name:
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CENTROMERE ANTIBODIES
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General Information
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Lab Order Codes:
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CENA
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Synonyms:
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Anti-Centromere Antibodies; ACA; CREST
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CPT Codes:
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83520 – Immunoassay for analyte other than infectious agent antibody or infectious agent antigen; quantitative, not otherwise specified
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Test Includes:
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Centromere antibody reported as negative or positive.
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Logistics
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Test Indications:
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Evaluating patients with clinical signs and symptoms compatible with systemic sclerosis including skin involvement, Raynaud’s phenomenon, and arthralgias.
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Lab Testing Sections:
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Serology - Sendouts
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Referred to:
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Mayo Medical Laboratories (Test# 9278)
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Phone Numbers:
Minneapolis:
Saint Paul:
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612-813-6280
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651-220-6550
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Test Availability:
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Daily, 24 hours
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Turnaround Time:
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1 – 2 days, test set up Monday through Saturday
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Special Instructions:
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N/A
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Specimen
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Specimen Type:
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Blood
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Container:
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Red top tube
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Draw Volume:
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1.5 mL blood
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Processed Volume:
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0.5 mL (Minimum: 0.35 mL) serum
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Collection:
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Routine venipuncture
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Special Processing:
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Lab Staff: Centrifuge specimen, remove serum aliquot into screw-capped round bottom plastic vial. Store and ship refrigerated. Forward promptly.
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Patient Preparation:
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None
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Sample Rejection:
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Specimens other than serum, warm specimens, gross hemolysis, gross lipemia, mislabeled or unlabeled specimens
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Interpretive
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Reference Range:
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All Ages:
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<1.0 U
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Negative
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≥1.0 U
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Positive
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Interpretation: In various reported clinical studies, Anti-Centromere Antibodies occur in 50-96% of patients with CREST syndrome.
A positive test for Centromere Antibodies is strongly associated with CREST syndrome. The presence of detectable levels of centromere antibodies may antedate the appearance of diagnostic clinical features of CREST syndrome, in some cases by several years.
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Critical Values:
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N/A
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Limitations:
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Centromere antibodies have also been described in some patients with primary biliary cirrhosis, and may occur in patients with rheumatoid arthritis or lupus erythematosus.
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Methodology:
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Multiplex Flow Immunoassay
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References:
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Mayo Medical Laboratory Web Page April 2011
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Updates:
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1/6/2006: CPT 2006 changes
11/1/2007: Addition of units and numeric reporting along with negative and positive results. Change in method, previously listed as EIA. CPT update, previously listed as 83516.
4/11/2011: CPT change from 88184 to 83520.
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