Clinics and Departments

Laboratory Services

Lab Dept:

Serology

Test Name:

OLIGOCLONAL BANDING, SERUM AND CSF

General Information

Lab Order Codes:

OLIB

Synonyms:

Oligoclonal Banding, CSF; Oligoclonal Banding, Spinal Fluid and Serum

CPT Codes:

83916 x2 – Oligoclonal immune

Test Includes:

Oligoclonal bands from CSF, from Serum and Interpretation

Logistics

Test Indications:

Useful for the diagnosis of multiple sclerosis; especially useful in patients with equivocal clinical presentation and radiological findings.

Lab Testing Sections:

Serology - Sendouts

Referred to:

Mayo Medical Laboratories (MML Test: 8017/OLIG)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

2 - 4 days, test set up Monday through Saturday

Special Instructions:

Both serum and spinal fluid are required for this test. Specimens must be drawn within 7 days of each other.

Specimen

Specimen Type:

Blood and CSF (See Special Instructions)

Container:

Blood: Red top tube

CSF: Screw capped, sterile vial

Draw Volume:

1.5 mL (Minimum: 1.2 mL) blood

0.5 mL (Minimum: 0.4 mL) CSF

Processed Volume:

0.5 mL (Minimum: 0.4 mL) serum

0.5 mL (Minimum: 0.4 mL) CSF

Collection:

Routine venipuncture and spinal fluid collection

Special Processing:

Lab Staff: Centrifuge blood specimen, remove serum aliquot and freeze in a screw capped round bottom plastic vial. Freeze processed serum and CSF specimens in separate plastic vials. Label appropriately with specimen type. Ship refrigerated. Forward promptly.

Patient Preparation:

None

Sample Rejection:

Specimens other than spinal fluid and serum; more than 7 days between CSF and serum collection times; CSF or serum collected alone; mislabeled or unlabeled specimens

Interpretive

Reference Range:

<4 bands

A finding of 4 or more CSF-specific bands is consistent with multiple sclerosis. The presence of oligoclonal bands is unrelated to disease activity.

Critical Values:

N/A

Limitations:

These tests are not specific for MS.

Methodology:

Isoelectric focusing (IEF) with IgG immunoblot detection

References:

Mayo Medical Laboratories Web Page August 2013



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