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Lab Dept:
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Serology
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Test Name:
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HEPATITIS DELTA ANTIBODY (ANTI-HDV)
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General Information
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Lab Order Codes:
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DELT
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Synonyms:
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Anti-Delta; HDV; Anti-HDV;
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CPT Codes:
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86692 – Antibody; hepatitis, delta agent
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Test Includes:
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Anti-HDV Total Aby; Hepatitis D Virus (HDV); Hepatitis D
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Logistics
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Test Indications:
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Diagnosis of concurrent HDV infection in HbsAg positive patients with newly diagnosed chronic HBV infection, known chronic HBV infection (HBsAg positive) with acute exacerbation, or fulminant HBV infection (HBsAg positive).
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Lab Testing Sections:
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Serology - Sendouts
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Referred to:
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Mayo Medical Laboratories (Test# FHEPD/91335). Forward to Focus Diagnostics (Focus# 24310)
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Phone Numbers:
Minneapolis:
Saint Paul:
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612-813-6280
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651-220-6550
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Test Availability:
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Daily, 24 hours
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Turnaround Time:
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3 - 7 days, test performed Monday and Thursday
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Special Instructions:
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N/A
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Specimen
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Specimen Type:
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Blood
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Container:
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Red top tube
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Draw Volume:
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3 mL (Minimum: 1.5 mL) blood
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Processed Volume:
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1 mL (Minimum: 0.5 mL) serum
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Collection:
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Routine venipuncture
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Special Processing:
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Lab Staff: Centrifuge specimen, remove serum aliquot into a screw-capped round bottom plastic vial. Store and ship at ambient temperature. Forward promptly.
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Patient Preparation:
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None
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Sample Rejection:
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Specimens other than serum; gross hemolysis; lipemia; mislabeled or unlabeled specimens
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Interpretive
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Reference Range:
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Negative (reported as positive, negative or equivocal)
Interpretive:
Negative – Antibody not detected
Equivocal – Submission of a second (collected 3-4 weeks after initial specimen) suggested if clinically warranted
Positive – Antibody detected
Hepatitis D virus (HDV) infection occurs in association with HBV infection. A positive result for HDV total antibody may indicate either acute or chronic HDV infection. HDV antibodies appear transiently during acute infection, and typically disappear with resolution of the infection. In contrast, HDV antibodies usually persist in chronic infection. Measurement of HDV IgM may help distinguish acute from chronic infection.
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Critical Values:
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N/A
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Limitations:
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This assay does not detect HDV antigen, which is present usually in the liver and is transient or not detectable in serum.
Performance characteristics of this assay have not been established for serum specimens having the following characteristics: lipemia, hemolysis, specimens containing particulate matter.
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Methodology:
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Enzyme Immunoassay (EIA)
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References:
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Mayo Medical Laboratories Web Page September 2012
Focus Diagnostics September 2012
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Updates:
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4/6/2004: Test moved from Memorial Blood Center of Minneapolis to Mayo Medical Laboratories.
9/30/2010: Mayo discontinued internal testing and began forwarding to Focus Diagnostics, 5785 Corporate Ave, Cypress, CA 90630. Storage temp change from frozen to ambient.
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