Clinics and Departments

Laboratory Services

Lab Dept:

Serology

Test Name:

HEPATITIS DELTA ANTIBODY (ANTI-HDV)

General Information

Lab Order Codes:

DELT

Synonyms:

Anti-Delta; HDV; Anti-HDV;

CPT Codes:

86692 – Antibody; hepatitis, delta agent

Test Includes:

Anti-HDV Total Aby; Hepatitis D Virus (HDV); Hepatitis D

Logistics

Test Indications:

Diagnosis of concurrent HDV infection in HbsAg positive patients with newly diagnosed chronic HBV infection, known chronic HBV infection (HBsAg positive) with acute exacerbation, or fulminant HBV infection (HBsAg positive).

Lab Testing Sections:

Serology - Sendouts

Referred to:

Mayo Medical Laboratories (Test# FHEPD/91335). Forward to Focus Diagnostics (Focus# 24310)

Phone Numbers:

Minneapolis:

Saint Paul:

 

612-813-6280

651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

3 - 7 days, test performed Monday and Thursday

Special Instructions:

N/A

Specimen

Specimen Type:

Blood

Container:

Red top tube

Draw Volume:

3 mL (Minimum: 1.5 mL) blood

Processed Volume:

1 mL (Minimum: 0.5 mL) serum

Collection:

Routine venipuncture

Special Processing:

Lab Staff: Centrifuge specimen, remove serum aliquot into a screw-capped round bottom plastic vial. Store and ship at ambient temperature. Forward promptly.

Patient Preparation:

None

Sample Rejection:

Specimens other than serum; gross hemolysis; lipemia; mislabeled or unlabeled specimens

Interpretive

Reference Range:

Negative (reported as positive, negative or equivocal)

Interpretive:

Negative – Antibody not detected
Equivocal – Submission of a second (collected 3-4 weeks after initial specimen) suggested if clinically warranted
Positive – Antibody detected

Hepatitis D virus (HDV) infection occurs in association with HBV infection. A positive result for HDV total antibody may indicate either acute or chronic HDV infection. HDV antibodies appear transiently during acute infection, and typically disappear with resolution of the infection. In contrast, HDV antibodies usually persist in chronic infection. Measurement of HDV IgM may help distinguish acute from chronic infection.

Critical Values:

N/A

Limitations:

This assay does not detect HDV antigen, which is present usually in the liver and is transient or not detectable in serum.

Performance characteristics of this assay have not been established for serum specimens having the following characteristics: lipemia, hemolysis, specimens containing particulate matter.

Methodology:

Enzyme Immunoassay (EIA)

References:

Mayo Medical Laboratories Web Page September 2012

Focus Diagnostics
September 2012

Updates:

4/6/2004: Test moved from Memorial Blood Center of Minneapolis to Mayo Medical Laboratories.
9/30/2010: Mayo discontinued internal testing and began forwarding to Focus Diagnostics, 5785 Corporate Ave, Cypress, CA 90630. Storage temp change from frozen to ambient.



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