Clinics and Departments

Laboratory Services

Lab Dept:

Serology

Test Name:

HEPATITIS Be ANTIGEN (HBeAg)

General Information

Lab Order Codes:

HBEA

Synonyms:

Hepatitis HBe Ag; HBeAg; Hepatitis Be Viral Antigen

CPT Codes:

87350 – Hepatitis Be antigen

Test Includes:

Hepatitis Be Antigen reported as positive, negative or equivocal.

Logistics

Test Indications:

Diagnosis and monitoring of hepatitis B virus infectivity. Recognition of resolution of hepatitis B infection with seroconversion of Hbe Ag to hepatitis Be antibody (anti-Hbe).

Lab Testing Sections:

Serology - Sendouts

Referred to:

Mayo Medical Laboratories (Test# EAG/80510)

Phone Numbers:

Minneapolis:

Saint Paul:

 

612-813-6280

651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

1 - 2 days; test performed Monday - Saturday

Special Instructions:

N/A

Specimen

Specimen Type:

Blood

Container:

Red top tube

Draw Volume:

3 mL (Minimum: 1.5 mL) blood

Processed Volume:

1 mL (Minimum: 0.5 mL) serum

Collection:

Routine venipuncture

Special Processing:

Lab Staff: Centrifuge specimen, remove serum aliquot into a screw-capped round bottom plastic vial. Store and ship at frozen temperatures. Forward promptly.

Patient Preparation:

None

Sample Rejection:

Specimens other than serum; warm specimens; gross lipemia; grossly icteric; gross hemolysis; mislabeled or unlabeled specimens

Interpretive

Reference Range:

Negative (reported as positive, negative or equivocal)

Presence of hepatitis Be antigen (HBeAg) usually indicates active hepatitis B virus (HBV) replication and infectivity.

Undetectable HBeAg with appearance of hepatitis Be antibody is consistent with resolution of HBV infectivity.

Equivocal HBeAg results indicate borderline levels of HBeAg in serum. Retesting in 1 to 2 months is recommended to determine definitive HBV infection status, if clinically indicated.

Critical Values:

N/A

Limitations:

Disappearance of hepatitis Be antigen does not completely rule out chronic hepatitis B carrier state and/or infectivity.

Performance characteristics have not been established for the following specimen characteristics:

- Grossly icteric (total bilirubin level >20 mg/dL)
- Grossly lipemic (triglyceride level >3,000 mg/dL)
- Grossly hemolyzed (hemoglobin level >100 mg/dL)
- Specimen containing particulate matter

Methodology:

Enzyme Immunoassay (EIA)

References:

Mayo Medical Laboratories September 2012

Updates:

4/6/2004: Test moved from Memorial Blood Center of Minneapolis to Mayo Medical Laboratories.



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