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Lab Dept:
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Serology
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Test Name:
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LIVER/KIDNEY MICROSOME TYPE I ANTIBODY
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General Information
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Lab Order Codes:
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LKMA
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Synonyms:
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Liver/Kidney Microsome Type 1 Antibodies, Serum; Antibodies to Liver/Kidney Microsome Type I; LKM1; Microsomal Liver/Kidney Type I
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CPT Codes:
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86376 – Microsomal antibodies
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Test Includes:
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Liver/Kidney Microsome Type 1 Antibody level in serum reported in Units.
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Logistics
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Test Indications:
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Useful for detecting a clinically specific antibody in patients with autoimmune chronic hepatitis (type 2). Evaluation of patients with liver disease of unknown etiology.
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Lab Testing Sections:
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Serology - Sendouts
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Referred to:
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Mayo Medical Laboratories (Test# 80387)
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Phone Numbers:
Minneapolis:
Saint Paul:
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612-813-6280
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651-220-6550
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Test Availability:
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Daily, 24 hours
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Turnaround Time:
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1 - 4 days, test set up Monday – Wednesday, Friday
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Special Instructions:
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N/A
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Specimen
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Specimen Type:
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Blood
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Container:
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Red top tube
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Draw Volume:
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1.5 mL (Minimum: 1.2 mL) blood
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Processed Volume:
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0.5 mL (Minimum: 0.4 mL) serum
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Collection:
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Routine venipuncture
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Special Processing:
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Lab Staff: Centrifuge specimen and aliquot 0.5 mL into a plastic screw cap vial. Store and ship at refrigerated temperatures. Forward promptly.
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Patient Preparation:
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None
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Sample Rejection:
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Specimens other than serum, gross hemolysis, warm specimens, gross lipemia, mislabeled or unlabeled specimens
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Interpretive
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Reference Range:
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≤20.0 Units
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Negative
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20.1 – 24.9 Units
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Equivocal
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≥25.0 Units
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Positive
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Reference values apply to all ages.
Interpretation: Seropositivity for anti-LKM-1 antibodies is consistent with a diagnosis of autoimmune hepatitis type 2.
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Critical Values:
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N/A
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Limitations:
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Serologic tests for autoantibodies, including anti-LKM-1, should not be relied upon exclusively to determine the etiology or prognosis of patients with liver disease.
Anti-LKM-1 antibodies may occur in some patients with chronic hepatitis caused by hepatitis C virus infection. Although the epitopes recognized by anti-LKM-1 antibodies in hepatitis C virus infection are different than in patients with autoimmune hepatitis type 2, physicians must use caution in interpreting the results of tests for anti-LKM-1 antibodies in such patients.
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Methodology:
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Enzyme-Linked Immunosorbent Assay (ELISA)
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References:
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Mayo Medical Laboratories Web Page April 2011
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