Clinics and Departments

Laboratory Services

Lab Dept:

Serology

Test Name:

LIVER/KIDNEY MICROSOME TYPE I ANTIBODY

General Information

Lab Order Codes:

LKMA

Synonyms:

Liver/Kidney Microsome Type 1 Antibodies, Serum; Antibodies to Liver/Kidney Microsome Type I; LKM1; Microsomal Liver/Kidney Type I

CPT Codes:

86376 – Microsomal antibodies

Test Includes:

Liver/Kidney Microsome Type 1 Antibody level in serum reported in Units.

Logistics

Test Indications:

Useful for detecting a clinically specific antibody in patients with autoimmune chronic hepatitis (type 2). Evaluation of patients with liver disease of unknown etiology.

Lab Testing Sections:

Serology - Sendouts

Referred to:

Mayo Medical Laboratories (MML Test: 80387/LKM)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

1 - 4 days, test set up Monday – Wednesday, Friday

Special Instructions:

N/A

Specimen

Specimen Type:

Blood

Container:

Red top tube

Draw Volume:

1.5 mL (Minimum: 1.2 mL) blood

Processed Volume:

0.5 mL (Minimum: 0.4 mL) serum

Collection:

Routine venipuncture

Special Processing:

Lab Staff: Centrifuge specimen and aliquot 0.5 mL into a plastic screw cap vial. Store and ship at refrigerated temperatures. Forward promptly.

Patient Preparation:

None

Sample Rejection:

Specimens other than serum, gross hemolysis, warm specimens, gross lipemia, mislabeled or unlabeled specimens

Interpretive

Reference Range:

≤20.0 Units

Negative

20.1 – 24.9 Units

Equivocal

≥25.0 Units

Positive

Reference values apply to all ages.

Interpretation: Seropositivity for anti-LKM-1 antibodies is consistent with a diagnosis of autoimmune hepatitis type 2.

Critical Values:

N/A

Limitations:

Serologic tests for autoantibodies, including anti-LKM-1, should not be relied upon exclusively to determine the etiology or prognosis of patients with liver disease.

Anti-LKM-1 antibodies may occur in some patients with chronic hepatitis caused by hepatitis C virus infection. Although the epitopes recognized by anti-LKM-1 antibodies in hepatitis C virus infection are different than in patients with autoimmune hepatitis type 2, physicians must use caution in interpreting the results of tests for anti-LKM-1 antibodies in such patients.

Methodology:

Enzyme-Linked Immunosorbent Assay (ELISA)

References:

Mayo Medical Laboratories Web Page July 2013



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