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Lab Dept:
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Serology
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Test Name:
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INNER EAR ANTIGEN
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General Information
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Lab Order Codes:
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IEA
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Synonyms:
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Anti-68kD (hsp-70) antibodies
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CPT Codes:
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84182 – Protein; Western blot, with interpretation and report, blood or other body fluid, immunological probe for band identification
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Test Includes:
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N/A
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Logistics
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Test Indications:
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A Western Blot Immunoassay has been recommended to identify serum antibodies that may be reacting against inner ear antigen(s). Studies suggest that hsp-70 is either the target antigen of the autoimmune response or has a shared antigenic epitope or represents an epiphenomenon that develops as a byproduct of inner ear damage. Regardless of its source, the presence of the autoantibody in sera of patients with progressive deafness is diagnostic of an immune-mediated cause of deafness and apparently predicts steroid sensitivity.
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Lab Testing Sections:
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Serology - Sendouts
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Referred to:
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Mayo Medical Laboratories (Test F68KD/91494) forward to Immco Diagnostics, Inc (Test# 340)
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Phone Numbers:
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MIN Lab: 612-813-6280
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STP Lab: 651-220-6550
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Test Availability:
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Daily, 24 hours
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Turnaround Time:
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4 to 7 days
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Special Instructions:
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N/A
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Specimen
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Specimen Type:
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Blood
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Container:
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Red top tube
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Draw Volume:
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9 mL (Minimum: 6 mL) blood
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Processed Volume:
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3 mL (Minimum: 2 mL) serum
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Collection:
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Routine venipuncture
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Special Processing:
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Lab Staff: Centrifuge specimen, remove aliquot and store and ship at refrigerated temperatures. Forward promptly.
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Patient Preparation:
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None
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Sample Rejection:
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Mislabeled or unlabeled specimens
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Interpretive
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Reference Range:
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Correlation of anti-68kD (hsp-70) Antibodies to Disease Activity
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Disease Activity
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Anti-68kD Antibody
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Active
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89%
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Inactive
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0%
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Critical Values:
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N/A
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Limitations:
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N/A
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Methodology:
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Western Blot
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References:
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Immco Diagnostics March 2013
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Mayo Medical Laboratories Web Page March 2013
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