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Lab Dept:
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Serology
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Test Name:
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ASPERGILLUS ANTIBODY
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General Information
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Lab Order Codes:
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ASAB
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Synonyms:
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A. fumigatis IgG Antibody; Aspergillus fumigatis IgG Antibody
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CPT Codes:
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86606 – Antibody; aspergillus
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Test Includes:
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Aspergillus fumigatus IgG only
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Logistics
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Test Indications:
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Useful for detection of antibodies in persons having aspergillosis, primarily allergic bronchopulmonary disease, or fungus ball.
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Lab Testing Sections:
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Serology - Sendouts
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Referred to:
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Mayo Medical Laboratories (MML Test: SASP)
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Phone Numbers:
Minneapolis:
Saint Paul:
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612-813-6280
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651-220-6550
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Test Availability:
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Daily, 24 hours
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Turnaround Time:
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1 - 3 days, test is set up Monday - Saturday
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Special Instructions:
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N/A
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Specimen
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Specimen Type:
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Blood
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Container:
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Red top tube, plain, no gel
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Draw Volume:
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1.5 mL (Minimum: 0.6 mL) blood
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Processed Volume:
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0.5 mL (Minimum: 0.2 mL) serum
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Collection:
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Routine venipuncture
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Special Processing:
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Lab Staff: Centrifuge specimen, remove serum and store refrigerated. Ship at refrigerated temperature.
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Patient Preparation:
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None
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Sample Rejection:
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Specimens other than serum, mislabeled or unlabeled specimens
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Interpretive
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Reference Range:
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Age:
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Reference range (mg/L):
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<4 years:
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Not established
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≥ 4 years:
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≤102 mg/L
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Elevated concentrations of IgG antibodies to Aspergillus fumigatis are consistent with the diagnosis of aspergillosis, either invasive disease or Hypersensitivity Pneumonitis. The levels of antibodies were often markedly elevated (>10 times the upper limit of normal), and there was no difference in subgroups of patients with Hypersensitivity Pneumonitis and cavitary disease with Hypersensitivity Pneumonitis.
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Critical Values:
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N/A
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Limitations:
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IgG antibodies to Aspergillus fumigatus are detectable in sera from healthy individuals, and the presence of antibodies is not sufficient to establish the diagnosis of aspergillosis.
The levels of antibodies often decrease following successful treatment; but elevated levels may persist for long periods. The measurement of IgG antibodies to Aspergillus fumigatis should not be relied upon exclusively to establish the diagnosis of aspergillosis.
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Methodology:
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Fluorescence Enzyme Immunoassay (FEIA)
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References:
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Mayo Medical Laboratories Web Page (August 2012)
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