Clinics and Departments

Laboratory Services

Lab Dept:

Serology

Test Name:

POLIOVIRUS TYPES 1, 2, 3 ANTIBODY

General Information

Lab Order Codes:

PVIS

Synonyms:

Poliovirus Antibody, Neutralization

CPT Codes:

86382 x3 – Neutralization, virus

Test Includes:

Poliovirus Type 1, 2 & 3 Antibody, each reported as a titer.

Logistics

Test Indications:

Assessing immunity following poliovirus vaccination, as well as determining the poliovirus serotype responsible for recent poliovirus infection. Also serves as an aid for diagnosing immune deficiency disorders.

Lab Testing Sections:

Serology - Sendouts

Referred to:

Mayo Medical Laboratories forward to Focus Diagnostics (MML Test: FPOLS)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

2 - 5 days, test set-up Monday and Thursday

Special Instructions:

N/A

Specimen

Specimen Type:

Blood

Container:

Red top tube

Draw Volume:

3 mL (Minimum: 1.5 mL) blood

Processed Volume:

1 mL (Minimum: 0.5 mL) serum

Collection:

Routine venipuncture

Special Processing:

Lab Staff: Centrifuge specimen, remove serum aliquot into a screw-capped round bottom plastic vial. Store and ship at refrigerated temperatures. Forward promptly.

Patient Preparation:

None

Sample Rejection:

Mislabeled or unlabeled specimen

Interpretive

Reference Range:

<1:8 Antibody not detected

≥1:8 Antibody detected

The presence of neutralizing serum antibodies (titers 1:8 up to >1:128) against polioviruses implies lifelong immunity. The serum neutralization test is type specific; antibodies detected against one type does not indicate immunity against other types. Some persons without detectable titers (<1:8) may also be immune as demonstrated by elicitation of a secondary-type serum antibody response upon challenge with live polio vaccine.

Critical Values:

N/A

Limitations:

N/A

Methodology:

Neutralization

References:

Mayo Medical Laboratories December 2013

Focus Diagnostics December 2013

Updates:

3/2/2004: Test moved form Lab Corp to MML (forward to Focus Laboratory). Test previously measured IgG antibody and now measure total antibody.
8/20/201212: Updated MML order code and reference range information.
12/16/2013: Method update, previously listed as Complement Fixation.

   


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