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Lab Dept:
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Serology
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Test Name:
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WEST NILE VIRUS IGG/IGM ANTIBODY
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General Information
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Lab Order Codes:
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WNV
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Synonyms:
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Arbovirus Ab; Flavivirus Ab; Viral Encephalitis; WNV Ab
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CPT Codes:
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86778 - West Nile Virus, IgM
86779 - West Nile Virus, IgG
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Test Includes:
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West Nile Virus IgG Antibody and West Nile Virus IgM Antibody
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Logistics
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Test Indications:
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Laboratory diagnosis of acute phase infection with West Nile Virus.
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Lab Testing Sections:
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Serology - Sendouts
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Referred to:
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Mayo Medical Laboratories (MML Test# 84186)
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Phone Numbers:
Minneapolis:
Saint Paul:
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612-813-6280
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651-220-6550
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Test Availability:
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Daily, 24 hours
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Turnaround Time:
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1 – 3 days, test setup Monday - Friday
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Special Instructions:
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N/A
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Specimen
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Specimen Type:
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Whole blood
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Container:
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Red top tube
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Draw Volume:
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1.5 mL (Minimum: 1.0 mL) blood
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Processed Volume:
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0.5 mL (Minimum: 0.25 mL) serum
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Collection:
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Routine venipuncture
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Special Processing:
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Lab Staff: Centrifuge specimen, remove serum aliquot into a screw-capped round bottom plastic vial. Store and ship at refrigerated temperatures. Forward promptly.
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Patient Preparation:
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None
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Sample Rejection:
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Warm specimens, hemolysis, lipemia
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Interpretive
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Reference Range:
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IgG: Negative
IgM: Negative
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Critical Values:
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N/A
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Limitations:
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Test results should be used in conjunction with a clinical evaluation and other available diagnostic procedures. The significance of negative test results in immunosuppressed patients is uncertain. Positive test results may not be valid in persons who have received blood transfusions or other blood products within the past several months.
False-negative results due to competition by high levels of IgG, while theoretically possible, have not been observed.
False-positive results may occur with persons vaccinated for flaviviruses (e.g., yellow fever, Japanese encephalitis, dengue), with persons infected with other flaviviruses, and with persons previously infected with West Nile Virus. Because closely related arboviruses exhibit serologic cross-reactivity, it sometimes may be epidemiologically important to attempt to pinpoint the infecting virus by conducting cross-neutralization tests using an appropriate battery of closely related viruses.
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Methodology:
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Enzyme-Linked Immunosorbent Assay (ELISA)
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Contraindications:
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N/A
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References:
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Mayo Medical Laboratories Web Page January 2007
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Updates:
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10/11/2004: CPT change from 86318 to 86790.
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1/12/2007: CPT 2007 updates
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