Clinics and Departments

Laboratory Services

Lab Dept:

Serology

Test Name:

CYCLIC CITRULLINATED PEPTIDE ANTIBODY, IGG

General Information

Lab Order Codes:

CCPA

Synonyms:

Anti-CCP; CCP; Anti-Citruline; Citrullinated Antibody

CPT Codes:

86200 – CCP antibody

Test Includes:

CCP antibody as negative, weak positive, positive or strong positive.

Logistics

Test Indications:

Useful for evaluating patients suspected of having rheumatoid arthritis (RA) and differentiating RA from other connective tissue diseases that may present with arthritis.

Lab Testing Sections:

Serology - Sendouts

Referred to:

Mayo Medical Laboratories (MML Test: 84182/CCP)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

1 – 3 days, test performed Monday – Saturday

Special Instructions:

N/A

Specimen

Specimen Type:

Blood

Container:

Red top tube

Draw Volume:

1.5 mL (Minimum: 1.2 mL) blood

Processed Volume:

0.5 mL (Minimum: 0.4 mL) serum

Collection:

Routine venipuncture

Special Processing:

Lab Staff: Centrifuge and aliquot serum into a screw-capped round bottom plastic vial. Store and ship refrigerated temperatures.

Patient Preparation:

None

Sample Rejection:

Gross hemolysis, warm specimens or gross lipemia; mislabeled or unlabeled specimens

Interpretive

Reference Range:

Reference values apply to all ages:

<20.0 U

Negative

20.0 – 39.9 U

Weak positive

40.0 – 59.9 U

Positive

≥60.0 U

Strong positive

Interpretation: A positive result for CCP antibodies indicates a high likelihood of rheumatoid arthritis.

Critical Values:

N/A

Limitations:

Positive results for CCP antibodies may occur in some patients with lupus erythematosus or other autoimmune, connective tissue diseases.

Antirheumatic therapy should not be initiated based solely on a positive test for CCP antibodies, and changes in treatment should not be based upon the levels of CCP antibodies.

Methodology:

Enzyme-Linked Immunosorbent Assay (ELISA)

References:

Mayo Medical Laboratories Web Page July 2013

Updates:

1/19/2006: CPT 2006 update
9/29/2008: Reference range and Units change



  Lab Test Directory
    Chemistry
    Coagulation
    Flow/Immunology
    Hematology
    Microbiology/ Virology
    Other Fluids
    Pathology
    Serology
    Transfusion Services
    Urine/Stool

  Search Lab Test Directory
    List All Documents

  Lab Staff

  E-mail Lab Services