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Lab Dept:
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Serology
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Test Name:
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CYCLIC CITRULLINATED PEPTIDE ANTIBODY
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General Information
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Lab Order Codes:
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CCPA
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Synonyms:
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Anti-CCP; CCP; Anti-Citruline; Citrullinated Antibody
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CPT Codes:
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86200 – CCP antibody
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Test Includes:
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CCP antibody as negative, weak positive, positive or strong positive.
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Logistics
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Test Indications:
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Useful for evaluating patients suspected of having rheumatoid arthritis (RA) and differentiating RA from other connective tissue diseases that may present with arthritis.
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Lab Testing Sections:
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Serology - Sendouts
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Referred to:
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Mayo Medical Laboratories (Test #84182)
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Phone Numbers:
Minneapolis:
Saint Paul:
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612-813-6280
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651-220-6550
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Test Availability:
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Daily, 24 hours
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Turnaround Time:
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1 – 3 days, test performed Monday – Saturday
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Special Instructions:
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N/A
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Specimen
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Specimen Type:
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Blood
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Container:
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Red top tube
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Draw Volume:
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1.5 mL (Minimum: 1.2 mL) blood
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Processed Volume:
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0.5 mL (Minimum: 0.4 mL) serum
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Collection:
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Routine venipuncture
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Special Processing:
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Lab Staff: Centrifuge and aliquot serum into a screw-capped round bottom plastic vial. Store and ship refrigerated temperatures.
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Patient Preparation:
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None
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Sample Rejection:
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Gross hemolysis, warm specimens or gross lipemia; mislabeled or unlabeled specimens
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Interpretive
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Reference Range:
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Reference values apply to all ages:
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<20.0 U
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Negative
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20.0 – 39.9 U
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Weak positive
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40.0 – 59.9 U
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Positive
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≥60.0 U
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Strong positive
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Interpretation: A positive result for CCP antibodies indicates a high likelihood of rheumatoid arthritis.
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Critical Values:
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N/A
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Limitations:
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Positive results for CCP antibodies may occur in some patients with lupus erythematosus or other autoimmune, connective tissue diseases.
Antirheumatic therapy should not be initiated based solely on a positive test for CCP antibodies, and changes in treatment should not be based upon the levels of CCP antibodies.
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Methodology:
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Enzyme Immunoassay (EIA)
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References:
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Mayo Medical Laboratories Web Page April 2011
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Updates:
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1/19/2006: CPT 2006 update
9/29/2008: Reference range and Units change
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