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Lab Dept:
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Serology
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Test Name:
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BETA-2 GLYCOPROTEIN 1 ANTIBODY
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General Information
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Lab Order Codes:
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B2GP1
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Synonyms:
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B2GP1 (Beta-2 Glycoprotein 1); Beta-2 GP1 Ab Panel, Serum; Beta 2 GP1 Ab IgA; Beta 2 GP1 Ab IgG; Beta 2 GP1 Ab IgM
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CPT Codes:
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86146 x3 - Beta 2 glycoprotein 1 antibody, each
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Test Includes:
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Beta 2 GP1 Ab IgG, IgM and IgA Antibodies
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Logistics
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Test Indications:
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Testing for beta-2 GP1 antibodies may be useful in the following clinical situations:
● Unexplained arterial or venous thrombosis
● A history of pregnancy morbidity defined as 1 or more unexplained deaths of a morphologically normal fetus beyond the 10th week of gestation, 1 or more premature births before 34 weeks of gestation caused by severe preeclampsia or placental insufficiency, or 3 or more unexplained, consecutive spontaneous abortions before the 10th week of gestation with no identifiable maternal hormonal or anatomic, or maternal or paternal chromosomal causes.
● Presence of an unexplained cutaneous circulatory disturbance, eg, livido reticularis or pyoderma gangrenosum.
● Unexplained thrombocytopenia or hemolytic anemia
● Possible nonbacterial, thrombotic endocarditis
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Lab Testing Sections:
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Serology - Sendouts
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Referred to:
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Mayo Medical Laboratories (Test# 88894)
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Phone Numbers:
Minneapolis:
Saint Paul:
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612-813-6280
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651-220-6550
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Test Availability:
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Daily, 24 hours
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Turnaround Time:
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1 - 6 days, set up on Tuesday and Thursday before 1 pm.
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Special Instructions:
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N/A
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Specimen
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Specimen Type:
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Whole blood
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Container:
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Red top tube
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Draw Volume:
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1.5 mL
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Processed Volume:
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0.5 mL serum
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Collection:
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Routine venipuncture
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Special Processing:
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Lab Staff: Centrifuge specimen, remove serum aliquot into a plastic screw-capped vial. Store and ship at refrigerated temperatures.
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Patient Preparation:
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None
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Sample Rejection:
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Specimens other than serum or sodium citrated plasma, mislabeled or unlabeled specimens, hemolysis, lipemia
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Interpretive
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Reference Range:
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Range (All ages)
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Interpretation
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<10.0 U/mL
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Negative
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10.0 - 14.9 U/mL
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Borderline
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≥15.0 U/mL
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Positive
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Results are expressed in arbitrary units and apply to IgG, IgM, and IgA values. Positive results for IgG and/or IgM beta-2 GP1 antibodies are consistent with antiphospholipid syndrome (APS). Detection of beta-2 GP1 antibodies is not affected by anticoagulant treatment.
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Critical Values:
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N/A
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Limitations:
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The clinical significance of low levels of IgG, IgM, and IgA antibodies to beta-2 GP1 is not clear.Testing for beta-2 GP1 antibodies cannot be relied upon to rule out antiphospholipid syndrome (APS). Results of tests for beta-2 GP1 antibodies are not well standardized, and results obtained with different immunoassays may vary substantially.
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Methodology:
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Enzyme-Linked Immunosorbent Assay (ELISA)
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References:
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Mayo Medical Laboratories Web Page April 2007
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