Clinics and Departments

Laboratory Services

Lab Dept:

Serology

Test Name:

BETA-2 GLYCOPROTEIN 1 (IgA, IgG, IgM) ANTIBODY PANEL

General Information

Lab Order Codes:

B2GP1

Synonyms:

B2GP1 (Beta-2 Glycoprotein 1); Beta-2 GP1 Ab Panel, Serum; Beta 2 GP1 Ab IgA; Beta 2 GP1 Ab IgG; Beta 2 GP1 Ab IgM

CPT Codes:

86146 x3 - Beta 2 glycoprotein 1 antibody, each

Test Includes:

Beta 2 GP1 Ab IgG, IgM and IgA Antibodies

Logistics

Test Indications:

Testing for beta-2 GP1 antibodies may be useful in the following clinical situations:

● Unexplained arterial or venous thrombosis
● A history of pregnancy morbidity defined as 1 or more unexplained deaths of a morphologically normal fetus beyond the 10th week of gestation, 1 or more premature births before 34 weeks of gestation caused by severe preeclampsia or placental insufficiency, or 3 or more unexplained, consecutive spontaneous abortions before the 10th week of gestation with no identifiable maternal hormonal or anatomic, or maternal or paternal chromosomal causes.
● Presence of an unexplained cutaneous circulatory disturbance, eg, livido reticularis or pyoderma gangrenosum.
● Unexplained thrombocytopenia or hemolytic anemia
● Possible nonbacterial, thrombotic endocarditis

Lab Testing Sections:

Serology - Sendouts

Referred to:

Mayo Medical Laboratories (Test# 88894/B2GP1)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

1 - 6 days, performed Monday - Saturday

Special Instructions:

N/A

Specimen

Specimen Type:

Blood

Container:

Red top tube

Draw Volume:

1.5 mL (Minimum: 1.2 mL) blood

Processed Volume:

0.5 mL (Minimum: 0.4 mL) serum

Collection:

Routine venipuncture

Special Processing:

Lab Staff: Centrifuge specimen, remove serum aliquot into a plastic screw-capped vial. Store and ship at refrigerated temperatures.

Patient Preparation:

None

Sample Rejection:

Specimens other than serum or sodium citrated plasma, mislabeled or unlabeled specimens, gross hemolysis, gross lipemia

Interpretive

Reference Range:

Range (All ages)

Interpretation

<10.0 U/mL

Negative

10.0 - 14.9 U/mL

Borderline

≥15.0 U/mL

Positive

Results are expressed in arbitrary units and apply to IgG, IgM, and IgA values. Positive results for IgG and/or IgM beta-2 GP1 antibodies are consistent with antiphospholipid syndrome (APS). Detection of beta-2 GP1 antibodies is not affected by anticoagulant treatment.

Critical Values:

N/A

Limitations:

The clinical significance of low levels of IgG, IgM, and IgA antibodies to beta-2 GP1 is not clear.Testing for beta-2 GP1 antibodies cannot be relied upon to rule out antiphospholipid syndrome (APS). Results of tests for beta-2 GP1 antibodies are not well standardized, and results obtained with different immunoassays may vary substantially.

Methodology:

Enzyme-Linked Immunosorbent Assay (ELISA)

References:

Mayo Medical Laboratories July 2013



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