Clinics and Departments

Laboratory Services

Lab Dept:

Serology

Test Name:

THYROPEROXIDASE (TPO) ANTIBODIES

General Information

Lab Order Codes:

THYP

Synonyms:

Antithyroid Antibodies; Hashimoto Disease; Microsomal Antibodies; Thyroid Antibody Group; Thyroid Microsomal Antibodies; Thyroid Peroxidase; TPO Antibodies

CPT Codes:

86376 - Microsomal antibodies

Test Includes:

Thyroperoxidase antibody level reported in IU/mL.

Logistics

Test Indications:

As an aid in the diagnosis of thyroid autoimmune disorders. Differentiating thyroid autoimmune disorders from non-autoimmune goiter or hypothyroidism. As a diagnostic tool in deciding whether to treat a patient who has subclinical hypothyroidism. See Mayo's Thyroid Function algorithm for more information.

Lab Testing Sections:

Serology - Sendouts

Referred to:

Mayo Medical Laboratories (MML Test: TPO)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

1 - 3 days, test performed Monday - Saturday

Special Instructions:

N/A

Specimen

Specimen Type:

Blood

Container:

Red top (plain, no gel) tube

Draw Volume:

1.8 mL (Minimum: 1.5 mL) blood

Processed Volume:

0.6 mL (Minimum: 0.5 mL) serum

Collection:

Routine venipuncture

Special Processing:

Lab Staff: Centrifuge specimen, remove serum aliquot into a plastic screw-capped round bottom vial. Ship and store at refrigerated temperatures. Forward promptly.

Patient Preparation:

None

Sample Rejection:

Gross hemolysis; mislabeled or unlabeled specimens

Interpretive

Reference Range:

<9.0 IU/mL

Note: Reference values apply to all ages

Critical Values:

N/A

Limitations:

Moderately increased levels of TPO antibodies may be found in patients with non-thyroid autoimmune disease such as pernicious anemia, type 1 diabetes, or other disorders that activate the immune system.

Methodology:

Chemiluminescent Immunoassay

References:

Mayo Medical Laboratories Web Page October 2014



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