Clinics and Departments

Laboratory Services

Lab Dept:

Serology

Test Name:

STRIATIONAL ANTIBODY, SERUM

General Information

Lab Order Codes:

STRM

Synonyms:

Striated Muscle Antibody; Anti-skeletal Muscle Antibody; Anti-Striated Antibody; Muscle (Skeletal) Antibodies; Myoid Antibody; Myasthenia Gravis Antibodies

CPT Codes:

83520 – Immunoassay, analyte, quantitative, not otherwise specified

Test Includes:

Striational antibody reported as a ratio.

Logistics

Test Indications:

As a serological aid in the diagnosis of thymoma, especially in patients with onset of Myasthenia Gravis younger than 45 years. It is more predictive of thymoma when accompanied by a muscle acetylcholine receptor (AchR) modulating antibody value of > or = 90% AchR loss and is most predictive of thymoma when accompanied by CRMP-5-IgG. It is useful as a screening test for Myasthenia Gravis in older patients, especially when tests for muscle AchR antibodies are negative. Serial measurements are useful in monitoring the efficacy of immunosuppressant treatment in patients with Myasthenia Gravis. Serial measurements are useful after treatment of thymoma. Measurements of muscle AchR binding, muscle AchR modulating antibody, and CRMP-5-IgG (if initially positive) are also recommended. Serial measurements in recipients of D-penicillamine or bone marrow allografts may be useful in monitoring autoimmune complications and graft-versus-host disease, respectively.

Lab Testing Sections:

Chemistry - Sendouts

Referred to:

Mayo Medical Laboratories (MML Test #: 8746/STR)

Phone Numbers:

Minneapolis:

Saint Paul:

 

612-813-6280

651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

3 - 5 days, performed Monday - Thurs

Special Instructions:

N/A

Specimen

Specimen Type:

Blood

Container:

Red top tube

Draw Volume:

1.5 mL (Minimum: 1 mL) blood

Processed Volume:

0.5 mL (Minimum: 0.3 mL) serum

Collection:

Routine venipuncture

Special Processing:

Lab Staff: Centrifuge specimen, remove serum into a screw-capped plastic vial. Store and ship and refrigerated temperatures.

Patient Preparation:

None

Sample Rejection:

Specimens other than serum; mislabeled or unlabeled specimens

Interpretive

Reference Range:

<1:60

Critical Values:

N/A

Limitations:

A negative result does not exclude the presence of thymoma (20% are negative)

Methodology:

Enzyme Immunoassay (EIA)

References:

Mayo Medical Laboratories Web Page January 2013



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