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Lab Dept:
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Serology
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Test Name:
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VZV IgM ANTIBODY
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General Information
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Lab Order Codes:
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VZIGM
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Synonyms:
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Anti-VZV Antibody IgM ; VZV IgM Serology; Varicella-Zoster IgM Antibody
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CPT Codes:
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86787 – Antibody, varicella zoster (IgM)
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Test Includes:
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Anti-VZV Antibody IgM reported as positive or negative.
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Logistics
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Test Indications:
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Intended for the qualitative detection of IgM antibodies to Varicella-Zoster diagnosing acute-phase infection.
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Lab Testing Sections:
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Immunology - Sendouts
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Referred to:
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Mayo Medical Laboratories (MML Test # 80964)
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Phone Numbers:
Minneapolis:
Saint Paul:
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612-813-6280
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651-220-6550
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Test Availability:
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Daily, 24 hours
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Turnaround Time:
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1 - 2 days; test performed daily
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Special Instructions:
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N/A
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Specimen
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Specimen Type:
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Blood
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Container:
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Red top tube
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Draw Volume:
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1.5 mL (Minimum: 0.6 mL) blood
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Processed Volume:
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0.5 mL (Minimum: 0.2 mL) serum
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Collection:
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Routine venipuncture
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Special Processing:
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Lab Staff: Centrifuge specimen, remove serum aliquot into a screw-topped plastic vial. Store and ship at refrigerated temperatures. Forward promptly.
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Patient Preparation:
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None
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Sample Rejection:
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Hemolyzed specimens; lipemic specimens; mislabeled or unlabeled specimens, specimens other than serum
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Interpretive
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Reference Range:
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Negative
A positive IgM result indicates a recent infection with VZV.
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Critical Values:
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N/A
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Limitations:
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A negative result does not rule out the diagnosis of VZV infection. Samples collected early in the course of a VZV infection may not have detectable levels of antibody. In such cases, it is recommended that a second serum sample be obtained 2-3 weeks later.
The performance characteristics with individuals vaccinated with VZV (OKA Strain) have not been established.
The test must be performed on serum. The use of whole blood, plasma or cord blood has not been established.
Positive results from cord blood or neonates should be interpreted with caution.
Results from immunocompromised patients should be interpreted with caution.
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Methodology:
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Immunofluorescence Assay (IFA)
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References:
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Mayo Medical Laboratories Web Page September 2010
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Updates:
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9/12/2005: Testing turnaround time previously listed as 1-6 days, testing performed 1 time per week.
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2/1/2006: Test moved from Children’s Hospitals and Clinics of Minnesota Laboratories to Mayo Medical Laboratories.
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