Clinics and Departments

Laboratory Services

Lab Dept:

Serology

Test Name:

CELIAC ASSOCIATED HLA-DQ TYPING

General Information

Lab Order Codes:

CELA

Synonyms:

HLA Celiac Disease Testing

CPT Codes:

81377 – HLA Class II typing, low resolution, one antigen equivalent, each
For non-participating payors: 86816 – HLA typing DR/DQ, single antigen

Test Includes:

HLA DQ Alpha 1 and HLA DQ Beta 1

Logistics

Test Indications:

Useful for assessing risk of celiac disease.

Celiac disease is mediated T lymphocytes in patients with genetic susceptibility. This genetic association is with certain HLA genes in the class II region (DQ alpha, DQ beta).

Lab Testing Sections:

Serology – Sendouts

Referred to:

Mayo Medical Laboratories (Test: CELI/88906)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

7 – 14 days

Special Instructions:

Please obtain special tube from the laboratory.

Specimen

Specimen Type:

Whole blood

Container:

Yellow-top (ACD [solution B]) tube

Draw Volume:

6 mL (Minimum: 3 mL) blood

Processed Volume:

Same as Draw Volume

Collection:

Routine venipuncture, mix by gentle inversion

Special Processing:

Lab Staff: Send 6 mL (Minimum: 3 mL) ACD (solution B) whole blood at refrigerated temperature. Do Not centrifuge. Do not transfer blood to other containers. Do Not freeze ACD (solution B) whole blood. Forward promptly.

Patient Preparation:

None

Sample Rejection:

Frozen specimens; mislabeled or unlabeled specimens

Interpretive

Reference Range:

Interpretive report

Critical Values:

N/A

Limitations:

Performance characteristics have been determined by Laboratory Medicine and Pathology, Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

Methodology:

Polymerase Chain Reaction (PCR)/Sequence –specific Oligonucleotide Probe (SSO) (PCR is utilized pursuant to a license agreement with Roche Molecular Systems, Inc.)

References:

Mayo Medical Laboratories September 2012

Updates:

1/19/2011: Method and CPT update.
1/4/2012: Storage temp changed from Ambient to Refrigerated, Draw volume changed from 7 to 6 mL.



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