Clinics and Departments

Laboratory Services

Lab Dept:

Serology

Test Name:

PARANEOPLASTIC AUTOANTIBODY EVALUATION, SERUM

General Information

Lab Order Codes:

PAES

Synonyms:

Acetylcholine Receptor (Muscle AchR) Antibodies; Ovarian Cancer-Related Antibodies; Isaacs Disease; VGVC (voltage-Gated Calcium Chanel) Antibodies; Anti-Purkinje Cell Cytoplasmic Antibodies

CPT Codes:

83519-59 x5 – Immunoassay for analyte; quantitative
86256 x9 – Fluorescent antibody titer

The following may be added with an additional charge based on findings:

83519-59 – Ach receptor (muscle) modulating antibodies (if appropriate)
84182 – Amphiphysin Western blot (if appropriate)
84182 – CRMP-5-IgG Western blot (if appropriate)
84182 – Paraneoplastic autoantibody Western blot confirm (if appropriate)
86255 – NMO-IgG (if appropriate)
86341 – GAD65 antibody assay (if appropriate)

Test Includes:

ANNA-1, ANNA-2, ANNA-3. AGNA-1, PCA-1, PCA-2, PCA-Tr, Amphiphysin Ab, CRMP-5-IgG, Striational Ab, P/Q-Type Calcium Channel Ab, N-Type Calcium Channel Ab, ACh Receptor (Muscle) Binding Ab, AChR Ganglionic Neuronal Ab, Neuronal (V-G) K+ Channel Ab.

Logistics

Test Indications:

Useful for serological evaluation of patients who present with a subacute neurological disorder of undetermined etiology, especially those with known risk factors for cancer; directing a focused search for cancer; investigating neurological symptoms that appear in the course of, or after, cancer therapy, and are not explainable by metastasis; differentiating autoimmune neuropathies from neurotoxic effects of chemotherapy; monitoring the immune response of seropositive patients in the course of cancer therapy; detecting early evidence of cancer recurrence in previously seropositive patients.

Lab Testing Sections:

Serology – Sendouts

Referred to:

Mayo Medical Laboratories (Test: PAVAL/83380)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

10 - 17 days

Special Instructions:

N/A

Specimen

Specimen Type:

Blood

Container:

Red top tube

Draw Volume:

12 mL (Minimum: 6 mL) blood

Processed Volume:

4 mL (Minimum: 2 mL) serum

Collection:

Routine venipuncture

Special Processing:

Lab Staff: Centrifuge specimen, remove serum from cells, aliquot into a screw-capped round bottom plastic vial. Store and ship at refrigerated temperatures. Forward promptly.

Patient Preparation:

None

Sample Rejection:

Gross hemolysis; gross lipemia; grossly icteric; mislabeled or unlabeled specimens

Interpretive

Reference Range:

Antibody:

Reference Range:

ANNA-1

<1:240

ANNA-2

<1:240

ANNA-3

<1:240

AGNA-1

<1:240

PCA-1

<1:240

PCA-2

<1:240

PCA-Tr

<1:240

Amphiphysin Ab

<1:240

CRMP-5-IgG

<1:240

N-Type Calcium Channel Ab

< or = 0.03 nmol/L

P/Q- Type Calcium Channel Ab

< or = 0.02 nmol/L

ACh Receptor (Muscles) Binding AB

< or = 0.02 nmol/L

AChr Ganglionic Neuronal Ab

< or = 0.02 nmol/L

Neuronal VGKC Autoantibody

< or = 0.02 nmol/L

Critical Values:

N/A

Limitations:

N/A

Methodology:

Indirect Immunofluorescence Assay (IFA), Enzyme Immunoassay (EIA), Radioimmunoassay (RIA), Western blot

References:

Mayo Medical Laboratories March 2013



  Lab Test Directory
    Chemistry
    Coagulation
    Flow/Immunology
    Hematology
    Microbiology/ Virology
    Other Fluids
    Pathology
    Serology
    Transfusion Services
    Urine/Stool

  Search Lab Test Directory
    List All Documents

  Lab Staff

  E-mail Lab Services