Clinics and Departments

Laboratory Services

Lab Dept:

Serology

Test Name:

STRONGYLOIDES ANTIBODY, IGG

General Information

Lab Order Codes:

STRNG

Synonyms:

N/A

CPT Codes:

86682 – Antibody, helminth, not elsewhere specified

Test Includes:

Strongyloides IgG antibody reported as Negative, Equivocal or Positive.

Logistics

Test Indications:

To aid in the diagnosis and confirmation of patients for whom a clinical suspicion of Strongyloides infection exists. Results for this test should not be used without correlation to clinical history or other data.

Strongyloidiasis is caused by the intestinal nematode, Strongyloides, as it migrates from the skin to the intestines. These nematodes may exist as free-living larvae in warm, moist tropical climates, or as non-infective larvae that pass in the stool of infected individuals and become infective while in the soil of temperate environments.

Strongyloides larvae enter the body by penetrating the skin and are carried through blood vessels to the lungs. The larvae travel from the lungs to the trachea and the pharynx, where they are swallowed and enter the intestines via the duodenum and upper jejunum.

Lab Testing Sections:

Serology - Sendouts

Referred to:

Mayo Medical Laboratories forward to ARUP (MML Test: FSAI, ARUP Test: 0099564)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

3 – 10 days

Special Instructions:

N/A

Specimen

Specimen Type:

Blood

Container:

Red top tube

Draw Volume:

3 mL (Minimum: 0.6 mL) blood

Processed Volume:

1 mL (Minimum: 0.05 mL) serum

Collection:

Routine venipuncture

Special Processing:

Lab Staff: Centrifuge specimen. Remove serum and aliquot into a plastic screw-capped tube. Store and ship at refrigerated temperatures. Forward promptly.

Patient Preparation:

None

Sample Rejection:

Warm specimens; mild or gross lipemia; mild or gross icterus; bacterially contaminated; heat-inactivated; mislabeled or unlabeled specimen

Interpretive

Reference Range:

Reference Interval (IV)

Reference Value

Interpretation

1.49 IV or less

Negative

No significant level of Strongyloides IgG antibody detected.

1.50 – 2.10 IV

Equivocal

Questionable presence of Strongyloides IgG antibody detected. Repeat testing in 10-14 days may be helpful.

2.11 IV or greater

Positive

IgG antibodies to Strongyloides detected, which may suggest current or past infection.

Critical Values:

N/A

Limitations:

  • This assay will detect the presence of serum IgG antibodies against Strongyloides species. While diagnosis may be made clinically, serologic antibody testing can aid in the diagnosis of Strongyloidiasis. However, cutaneous larva migrans is observed with infections by other nematodes, such as Ancylostoma species, Uncinaria stenocephala, and Bunostomum phlebotomum. Additionally, antibody cross-reactions in patients with filariasis may occur.
    The enzyme immunoassay for Strongyloides antibody detection is recommended in the place of IFA or IHA due to its sensitivity, which ranges from 84 to 92 percent. However, 8-16 percent of individuals infected with Strongyloides are sero-negative, so false-negative results cannot be ruled out. Additionally, since this assay measures Strongyloides-specific IgG in patient samples, test results from single samples cannot be used to differentiate between current and past infections.

Methodology:

Semi-quantitative Enzyme-Linked Immunosorbent Assay (ELISA)

References:

Mayo Medical Laboratories October 2013

ARUP Laboratories October 2013



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