Clinics and Departments
CHILDREN’S HOSPITALS AND CLINICS OF MINNESOTA
GUIDELINES FOR THE TRANSFUSION OF BLOOD COMPONENTS
These guidelines have been developed in conjunction with the hospital Transfusion Committee. They are based on widely accepted transfusion practices and reflect current literature and experience. The guidelines provide general clinical indications for transfusion therapy of each blood component, but may not be all-inclusive. Patients who receive blood components according to the guidelines may or may not actually benefit. Alternatively, some transfusions that are not included in the guidelines may be justified under special circumstances. These guidelines may be revised under appropriate circumstances and will be reviewed on a biennial basis. Note: The term neonate is used to refer to infants less than 44 weeks corrected gestational (post menstrual) age.
These guidelines incorporate the transfusion criteria used in ongoing quality assurance blood utilization review as required by The Joint Commission (TJC). It is important that the provider documents the patient's need for transfusion on the transfusion request order with each new order and specifies the indication for transfusion.
All RBC components (excluding autologous collection) and platelet components are leukoreduced pre-storage. These products are considered CMV safe. Therefore, CMV seronegative blood products do not need to be specifically ordered. Leukoreduced blood products are not equivalent to irradiated blood products in preventing Graft vs. Host Disease (GVHD). Irradiated blood products must be ordered for patients with specific conditions placing them at risk for GVHD as specified in this document.
The provider should discuss the risks, benefits and alternatives to transfusion with the patient, parent or guardian for all non-emergency transfusions and provide an opportunity to ask questions, and to accept or refuse transfusion. Consent for transfusion must be obtained for non-emergency transfusion episodes. The Circular of Information as well as local blood center pamphlets are available to assist the provider in this role. Additional questions may be referred to the hospital Transfusion Service, Minneapolis campus 612-813-6824, St Paul campus 651-220-6550. Information is also available on the following Internet sites: http://www.aabb.org/, http://www.americasblood.org/, http://www.mybloodyourblood.org/, and http://www.redcross.org/.
I. LEUKOCYTE REDUCED RED BLOOD CELL CONCENTRATES (includes packed red blood cells, washed red blood cells, frozen deglycerolized cells)
A. Acute blood loss (hemorrhage, surgery or iatrogenic) greater than 15% total blood volume (estimated blood volume = 70 mL/kg body weight) or 10% total blood volume in neonates (estimated blood volume 85 mL/kg) associated with:
1. Signs and symptoms of hypovolemia (tachycardia, tachypnea,
2. Signs and symptoms of cerebral or coronary hypoxia, fatigue, weakness, dizziness or respiratory distress.
3. In neonates < 7 days old when the cumulative blood volume removed over a one-week period due to laboratory testing exceeds 10% of the infant's estimated blood volume.
B. Patients with present symptoms of anemia or at high risk to develop symptoms of anemia with any of the following.
1. Hemoglobin less than 7 gm/dL
2. Hemoglobin less than 10 gm/dL and:
4. Hemoglobin less than 15 gm/dL and:
C. Exchange transfusion
D. To prime medical devices used during:
1. Acute treatment of patients with sickle cell disorders who are symptomatic (cerebral symptoms, splenic, pulmonary or hepatic sequestration, priapism, or other sickle cell crisis).
2. Asymptomatic sickle cell disease if scheduled to undergo general anesthesia for surgical or therapeutic procedures.
3. Transfusion dependent (thalassemias)
4. Scheduled erythrocytapheresis, hypertransfusion, or exchange transfusion for prevention of stroke, or in-patients with history of significant sickle cell complications.
II. LEUKOCYTE REDUCED PLATELET PHERESIS
NOTE: A single donor platelet pheresis (containing greater than 3 X 1011 platelets) is equivalent to 5-6 random donor platelet units (each containing greater than 5.5 x 1010 platelets).
A. Active bleeding or at high risk of life threatening bleed with qualitative platelet defect regardless of platelet count due to:
B. Life or organ threatening bleeding during surgery, regardless of platelet count
C. With massive blood replacement of greater than 50% of total blood volume within 8 hours
D. Platelet count less than 150,000 per mm3 for patients on ECMO. (See specific ECMO guidelines)
E. Platelet count less than 100,000 per mm3 under the following conditions:
1. CNS bleed
2. Neonate major surgery
3. Associated with neurologic, cardiovascular, ophthalmologic, or other surgical procedures with potentially life or organ threatening blood loss during the perioperative time. (preoperative, intraoperative, up to 7 days postoperative)
F. Platelet count less than 50,000 per mm3 under the following conditions:
1. Critical Neonate Sepsis/NEC/DIC
2. Neonate <32 weeks gestational age and <7 days old
3. Active bleeding or invasive procedure
G. Platelet count less than 30,000 per mm3 in low risk preterm neonate.
H. Platelet count less than 20,000 per mm3 in term neonate, no other risk factors.
I. Platelet count less than 10,000 per mm3 with consumption and decreased production.
III. FROZEN PLASMA (FP) / FRESH FROZEN PLASMA (FFP)
A. Documented coagulopathy: PTT greater than 50 seconds (>60 seconds in
B. Patients with suspected coagulopathy and excessive bleeding and coagulation studies are pending (or unable to obtain) at the time of the transfusion.
C. Patients undergoing cardiopulmonary bypass surgery or ECMO at risk for coagulopathy and bleeding.
D. Exchange transfusions
E. Massive blood loss (greater than 50% blood volume).
F. Replacement therapy during therapeutic plasma exchange for disorders in which Frozen Plasma is beneficial (HUS/TTP).
G. Replacement therapy with one of the following:
NOTE: Cryoprecipitate contains coagulation Factor VIII:C, Factor XIII, von Willebrand factor (factor VIII:vWf) and fibrinogen.
A. Fibrinogen <200 mg/dL and <48 hours post cardiovascular bypass or ECMO.
B. Fibrinogen < 100 mg/dL with one of the following:
C. Dysfibrinogenemia with active bleeding or within 24 hours of invasive
D. Patients with factor VIII deficiency or von Willebrand's disease, although specific factor concentrates are preferred.
E. Patients with factor XIII deficiency and active bleeding or within 24 hours of invasive procedure.
F. Use as topical ingredient for invasive procedures, although proprietary products may be available.
G. Massive blood loss (greater than 50% blood volume)
V. WHITE BLOOD CELLS
NOTE: All granulocyte product transfusions require pathology consultation and must be ordered 24 hours in advance for donor preparation and product processing.
The use of white blood cell products is controversial and all usage will be audited. Granulocyte concentrates contain considerable numbers of lymphocytes, platelets and red cells. Red cell compatibility testing is to be performed prior to transfusion.
5% and 25% albumin is available through Children’s Pharmacy.
VII. FACTOR CONCENTRATES IN PATIENTS WITH HEMOPHILIA AND OTHER HEREDITARY BLEEDING DISORDERS
The treatment of patients with hemophilia and other rare hereditary bleeding disorders is complex and requires consultation with a pediatric Hematologist/Oncologist and coordination with Children’s Pharmacy.
VIII. OTHER PRODUCTS
Immunoglobulins directed against viral or other undesirable antigens may be indicated in certain immunodeficient patients. The availability and composition of such products is variable. Consultation with a pediatric Hematology/
Oncology, and/or Infectious Disease are required. Immune Globulins are available through Children’s Pharmacy.
GUIDELINES FOR SELECTION OF SPECIAL BLOOD COMPONENTS
I. IRRADIATED COMPONENTS
Required only for cellular products including leukocyte reduced Red Blood
A. Documented or suspected, acquired or congenital immunodeficiency disorders
B. Infants < 4 months old throughout the admission period
C. Therapy induced immunosuppression (aggressive chemotherapy, immunotherapy, or extensive radiation therapy)
D. Granulocyte concentrates/buffy coats
E. Directed donations from blood relatives
F. HLA-matched apheresis platelets/crossmatch compatible platelets
G. Exchange transfusion in newborns
II. FROZEN DEGLYCEROLIZED RED BLOOD CELLS
A. Patients with IgA deficiency and antibodies to IgA
B. Patients with unusual antigenic phenotypes
III. WASHED BLOOD COMPONENTS
A. Severe transfusion reactions related to plasma proteins
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