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Lab Dept:
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Transfusion Services
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Test Name:
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PLATELET TRANSFUSION
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General Information
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Lab Order Codes:
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TPLT
Special charges:
HLA Matched-MHLA, AHLA
PLA1 Negative – PLAT, APLA1
Platelet Crossmatching PLTX – CPLT
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Synonyms:
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Leukocyte Reduced Platelets; Random Platelets; Platelet Rich Plasma; Platelet concentrate; Leukocyte Reduced Platelet Pheresis; Single-Donor Platelets; SDP Platelet pheresis; Apheresis Platelets; LRPH
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CPT Codes:
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P9035 – Platelet pheresis, Leukocyte reduced
86806 – Lymphocytotoxicity assay, visual crossmatch, without titration
86813 – HLA Matched
86945 – Irradiation
86985 – Volume Reduction
86965 – Pooling
86903 – Platelet Antigen typing
86999 – Washing
86022 – Platelet Crossmatch
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Test Includes:
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Leukocyte Reduced Platelet Pheresis consists of platelets suspended in 200-300 mL of plasma collected by cytapheresis. Each unit contains at least 3 x 1011 platelets, and ≤5.0 x 106 leukocytes. One pheresis unit equals 5-6 random unit platelet concentrate.
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Logistics
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Test Indications:
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Refer to Guidelines for the Transfusion of Blood Components.
Platelet Crossmatching or HLA-Matched Platelets may be useful for patients receiving repeated platelet transfusions who have become refractile, and for patients who repeatedly develop febrile non-hemolytic transfusion reactions after platelet transfusions.
Volume Reduced Platelets are indicated in the event that ABO - incompatible platelets must be transfused due to availability or in patients with severe fluid restrictions. Refer to Blood Component Compatibility Chart
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Lab Testing Sections:
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Transfusion Services
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Phone Numbers:
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MIN Lab: 612-813-6824
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STP Lab: 651-220-6558
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Test Availability:
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Daily, 24 hours
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Turnaround Time:
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1 - 2 hours
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Standard Dose/Volume:
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<10 kg: 10 – 15 mL/kg up to one unit or 50 mL maximum
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10 – 15 kg: 1/3 pheresis unit
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15 – 25 kg: 1/2 pheresis unit
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>25 kg: 1 pheresis unit
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Rate of Infusion:
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10 minutes/unit, <4 hours
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Administration:
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Must be administered through a blood component administration filter. Volumes ≤60 mL may be issued by the Transfusion Service in prefiltered syringes.
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Crossmatch:
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Platelets must be ABO/Rh compatible. Crossmatch is not required.
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Irradiation:
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Yes for specific patient populations.
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Order Instructions:
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Indicate number of units or volume in mL’s; time and dose needed; and indication for transfusion.
Specify on the Transfusion Request Order Form special needs: Irradiate, Volume Reduce, Washed, Platelet Crossmatch, PLA1 negative, HLA matched.
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Expiration:
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Store at 20 – 24ºC with continuous agitation for 5 days. Pooled or aliquoted platelet transfusions must begin within 4 hours of preparation.
Do Not refrigerate.
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Specimen
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Specimen Type:
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Refer to ABO/Rh if patient requires testing
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Patient Preparation:
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The patient must have a Medical Records band for checking against the component Unit Tag and the Transfusion Request Order Form prior to administration.
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Interpretive
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Methodology:
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Platelets contain stable coagulation factors and labile factors V and VIII. Refer to Blood Component General Information for greater detail.
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Contraindications:
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Refer to Guidelines for Transfusion of Blood Components.
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References:
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Circular of Information of the Use of human Blood and Blood Components (2002) AABB, American Red Cross, America’s Blood Centers
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Updates:
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11/08/2004: Note change to platelet dosage for patients <20 kg.
8/07/2007: Update for platelet dosage levels.
2/12/2013: CPT update
3/12/2013: Removed references to pooled platelets
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