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Lab Dept:
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Urine/Stool
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Test Name:
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17-HYDROXYPROGESTERONE, URINE
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General Information
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Lab Order Codes:
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17HU
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Synonyms:
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17-Hydroxy Progesterone, Urine; 17-OH Progesterone, Urine
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CPT Codes:
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83498 – Hydroxyprogestone, 17-d
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Test Includes:
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Total Urine 17-Hydroxyprogesterone level measured in ug/24 hours and Urine Creatinine measured in ng/mg creatinine.
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Logistics
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Test Indications:
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17-Hydroxy Progesterone is a steroid derived from enzymatic metabolism of Progesterone and 17-Hydroxy Pregnenolone. It is converted enzymatically to Androstenedione and 11-Deoxycortisol. It is produced in both the gonads and adrenal glands. It is excreted into the urine in conjugated and unconjugated forms of 17-Hydroxy Progesterone and as Pregnanetriol. This assay measures the total of the conjugated and unconjugated forms. It is stimulated by ACTH and suppressed by Dexamethasone. Levels of urine 17-Hydroxy Progesterone are greatly increased in patients with Polycystic Ovarian Disease and Congenital Adrenal Hyperplasia and show exaggerated responses to ACTH in these cases. 17-Hydroxy Progesterone is the marker steroid for determining cases of 21a-Hydroxylase Deficient Congenital Adrenal Hyperplasia. Urine levels are frequently elevated in patients with idiopathic hirsutism.
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Lab Testing Sections:
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Urine/Stool - Sendouts
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Referred to:
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Mayo Medical Laboratories (MML Test# 90170) and forwarded to Inter Science Institute
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Phone Numbers:
Minneapolis:
Saint Paul:
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612-813-6280
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651-220-6550
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Test Availability:
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Daily, 24 hours
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Turnaround Time:
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2 – 7 days; performed Monday - Friday
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Special Instructions:
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Refrigerate or keep specimen on ice during 24 hour collection. There is no preservative. See Patient Preparation.
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Specimen
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Specimen Type:
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Urine, 24 hour collection
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Container:
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Plastic, leak-proof urine collection container
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Draw Volume:
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Entire collection
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Processed Volume:
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5.0 mL of urine from a well-mixed 24 hour collection
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Collection:
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Routine 24 hour urine collection, refrigerate or keep on ice
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Special Processing:
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Lab Staff: Mix 24 hour specimen well. Measure and record total urine volume. Remove 5.0 mL aliquot into a screw-capped round bottom plastic vial. Store and ship at frozen temperatures. Forward promptly.
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Patient Preparation:
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Patient should not be on any Corticosteriod, ACTH, steroid, estrogen, or gonadotropin medication, if possible, for at least 48 hours prior to start of urine collection.
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Sample Rejection:
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Specimens other than urine, mislabeled specimens
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Interpretive
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Reference Range:
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17-Hydroxyprogesterone:
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Age
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Range
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3 days – 1 year:
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Up to 50 ng/24 hours
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1 – 8 years:
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Up to 300 ng/24 hours
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Adult Males:
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Up to 2.0 ug/24 hours
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Adult Females:
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Up to 4.5 ug/24 hours
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Creatinine:
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3 days – 1 year:
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Up to 0.10 ng/mg creatinine
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1 – 8 years:
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Up to 0.50 ng/mg creatinine
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Adult Males:
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Up to 1.00 ng/mg creatinine
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Adult Females:
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Up to 2.00 ng/mg creatinine
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Critical Values:
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N/A
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Limitations:
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N/A
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Methodology:
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Radioimmunoassay (RIA) following extraction of specimens
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Contraindications:
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N/A
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References:
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Mayo Medical Laboratory Web Page http://www.mayoreferenceservices.org/mrs/mml/mml-test.asp May 2005
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