Children's Hospitals and Clinics of Minnesota
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Lab Dept:

Urine/Stool

Test Name:

BLASTOMYCES ANTIGEN, URINE

General Information

Lab Order Codes:

BAG

Synonyms:

N/A

CPT Codes:

87449 – Infectious agent antigen detection by EIA technique

Test Includes:

Urine Blastomyces Antigen level reported in EIA Units.

Logistics

Test Indications:

Aid in diagnosis of disseminated or acute pulmonary blastomycosis.

Lab Testing Sections:

Urine/Stool - Sendouts

Referred to:

Mayo Medical Laboratories (MML Test# 91407 forward to MiraVista Diagnostics)

Phone Numbers:

Minneapolis:

Saint Paul:

 

612-813-6280

651-220-6550

Test Availability:

Daily, 24 hours, test performed Monday - Friday

Turnaround Time:

1 - 3 days

Special Instructions:

N/A

Specimen

Specimen Type:

Urine, random

Other specimen types tested: Bronchoalveolar Lavage (BALF) or Sterile Body Fluid

Container:

Sterile leak-proof container

Draw Volume:

2.0 mL urine (or other acceptable specimen type)

Processed Volume:

Same as Draw Volume

Collection:

Routine urine collection

Special Processing:

Lab Staff: Mix random urine sample well. Remove aliquot into a plastic, 13 mL urine tube. Store and ship at refrigerated temperatures. Forward promptly.

Patient Preparation:

None

Sample Rejection:

Mislabeled or unlabeled specimens

Interpretive

Reference Range:

EIA Units

Result Interpretation

Equivocal

Results inconclusive after repeated testing

<1.0

Negative

1.0 – 2.0

Weak positive; suggest repeat

2.1 – 4.0

Positive; repeat if inconsistent with clinical findings

4.1 – 10.0

Moderate positive

>10.0

High positive

Follow-up Testing Only (comparing to previous specimen tested in the same assay

Increase:

< or = 2.0

Stable*
*No change: Increases or decreases <2.0 units are considered no change.

2.1 – 4.0

Mild increase; possible failure; probable failure

>4.0

Moderate to marked increase; probable failure

Decrease:

 

Current specimen having >2.0 unit decrease compared to result of prior specimen tested in the same assay is interpreted as having a decreased antigen level.

Test performed by:
MiraVista Diagnostics
444 Decatur Blvd., Suite 300
Indianapolis, IN 46241

Critical Values:

N/A

Limitations:

Heterophile antibodies and rheumatoid factor can cause positive interference. Cross-reactions due to closely related antigenic epitopes are seen in patients with histoplasmosis, paracoccidioidomycosis, and penicilliosis. Rare cross-reactions have been seen in patients with aspergillosis and cryptococcosis.

Methodology:

EIA (Enzyme Immunoassay)

Contraindications:

N/A

References:

Mayo Medical Laboratories July 2009

Updates:

7/2/2009: Added other specimen types (BALF, other sterile body fluids)