Clinics and Departments

Laboratory Services

Lab Dept:

Urine/Stool

Test Name:

HYPEROXALURIA PANEL, URINE

General Information

Lab Order Codes:

UHPU

Synonyms:

N/A

CPT Codes:

82544 – Column chromatography/mass spectrophotometry; stable isotope dilution, multiple analytes, quantitative, single stationary and mobile phase

Test Includes:

Glycolate, glycorate, oxalate, and glyoxylate levels reported in mg/g Creatinine.

Logistics

Test Indications:

Useful for distinguishing between primary and secondary hyperoxaluria; distinguishing between Type I and Type II primary hyperoxaluria.

Lab Testing Sections:

Urine/Stool - Sendouts

Referred to:

Mayo Medical Laboratories (MML Test: HYOX)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

10 – 14 days

Special Instructions:

See Patient Preparation:

Specimen

Specimen Type:

Urine, See Patient Preparation:

Container:

Plastic leak-proof urine container (no preservative)

Draw Volume:

Entire Random urine collection

Processed Volume:

10 mL (Absolute minimum: 1.1 mL) random urine

Collection:

Routine random urine collection

Special Processing:

Lab Staff: Remove urine aliquot from a well-mixed specimen. Place aliquot into a 10 mL urine tube. Freeze immediately. Store and ship at frozen temperatures. Forward promptly.

Patient Preparation:

Fasting overnight (12-14 hours, recommended). Have patient void the first-morning specimen, then collect specimen within 2 hours of the first-morning void while the patient continues to fast. Fluids are allowed.

Sample Rejection:

Specimens other than urine; mislabeled or unlabeled specimens

Interpretive

Reference Range:

Analyte

Age

Range (mg/g creatinine)

Glycolate

0 – 31 days

0 - 57

1 – 5 months

0 - 54

6 – 12 months

0 - 60

1 – 5 years

0 - 89

>or = 6 years

0 - 78

Glycerate

0 – 31 days

0 - 38

1 – 5 months

0 - 71

6 – 12 months

0 - 56

1 – 5 years

0 - 17

>or = 6 years

0 - 8

Oxalate

0 – 31 days

0 - 301

1 – 5 months

0 - 398

6 – 12 months

0 - 280

1 – 5 years

0 - 128

6 – 10 years

0 - 72

>or = 10 years

0 - 56

Glyoxylate

0 – 31 days

0.0 – 7.9

1 – 5 months

0.0 – 11.4

6 – 12 months

0.0 – 5.5

1 – 5 years

0.0 – 3.9

>or = 6 years

0.0 – 2.9

Interpretation:

Increased concentrations of oxalate and glycolate indicate Type I hyperoxaluria.

Increased concentrations of oxalate and glycerate indicate Type II hyperoxaluria.

Increased concentrations of oxalate with normal concentrations of glycolate and glycerate indicate secondary hyperoxaluria.

Critical Values:

N/A

Limitations:

Ascorbic acid will falsely elevate oxalic acid results.

Methodology:

Gas chromatography – Mass spectrometry (GC-MS)

References:

Mayo Medical Laboratories March 2013



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