Clinics and Departments

Laboratory Services

Lab Dept:


Test Name:


General Information

Lab Order Codes:



Cu, blood

CPT Codes:

82525 - Copper

Test Includes:

Copper level reported in mcg/mL.


Test Indications:

Useful for diagnosis of Wilson’s disease, primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC).

In normal serum, more than 95% of the copper is incorporated into the enzyme, ceruloplasmin; the remaining copper is loosely bound to albumin. A deficiency in copper results in severe derangement in growth and metabolism and impairment of erythropoiesis.

Lab Testing Sections:

Chemistry - Sendouts

Referred to:

Mayo Medical Laboratories (MML Test: 8612/CUS)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

1 - 3 days

Special Instructions:

See Container and Collection and Patient Preparation for special requirements.


Specimen Type:



Plain (NO ADDITIVE), Royal blue-top Vacutainer plastic trace element blood collection tube (Mayo Supply T184). Contact lab with questions regarding this tube.

Draw Volume:

2.4 mL (Minimum: 0.6 mL) blood

Processed Volume:

0.8 mL (Minimum: 0.2 mL) serum

Note: Submission of the minimum volume does not allow repeat analysis.


Use stainless steel needle or butterfly vacutainer collection. Collect in a royal blue top tube (See Container). Avoid hemolysis.

Special Processing:

Lab Staff: Blood specimens for serum testing should be collected in the royal blue-top Monoject® Trace Element Blood Collection Tube.

1. Allow the specimen to clot for 30 minutes; then centrifuge the specimen to separate serum from the cellular fraction within 4 hours of specimen collection.

2. Remove the stopper and carefully pour 0.4 mL serum into a 7 mL, Mayo metal free, screw-capped, polypropylene vial (Mayo Supply T173), avoiding transfer of the cellular components of blood. Do Not insert a pipet into the serum to accomplish transfer, and Do Not ream the specimen with a wooden stick to assist with serum transfer.

3. Place the cap on the polypropylene vial tightly, attach a specimen label and send specimen to the laboratory at refrigerated or frozen temperature.

Patient Preparation:

Gadolinium is known to interfere with most metal tests. If gadolinium-containing contrast media has been administered, a specimen cannot be collected for 48 hours

Sample Rejection:

Specimens other than serum; mislabeled or unlabeled specimens


Reference Range:


Reference Range (mcg/mL)

0 – 2 mos.

0.40 – 1.40 mcg/mL

3 – 6 mos.

0.40 – 1.60 mcg/mL

7 – 9 mos.

0.40 – 1.70 mcg/mL

10 – 12 mos.

0.80 – 1.70 mcg/mL

13 mos. – 10 yrs.

0.80 – 1.80 mcg/mL

≥11 yrs.

0.75 – 1.45 mcg/mL

Critical Values:



Gadolinium is known to interfere with most metal tests. If gadolinium-containing contrast media has been administered, a specimen cannot be collected for 48 hours.


Dynamic Reaction Cell DRC) II Inductively Coupled Plasma Mass Spectrophotometry (DRC-ICP-MS)


Mayo Medical Laboratories Web Page October 2014


11/11/2008: Reference range previously reported as 0.75 - 1.45 µg/mL for all ages. New reference ranges have now been established for pediatrics.
4/6/2010: Method change; previously listed as Inductively Coupled Plasma (ICP) Emission Spectroscopy
9/9/2014: Clarification of tube type.

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