Clinics and Departments

Laboratory Services

Lab Dept:

Chemistry

Test Name:

C-REACTIVE PROTEIN (CRP)

General Information

Lab Order Codes:

CRP

Synonyms:

C-Reactive Protein Quantitative ,Plasma or Serum; CRP

CPT Codes:

86140 – C-reactive protein

Test Includes:

C-Reactive protein concentration reported in mg/dL.

Logistics

Test Indications:

C-Reactive protein is one of the acute phase proteins, the serum or plasma levels of which rise during a general, unspecific response to infections and non-infectious inflammatory processes such as rheumatoid arthritis, cardiovascular disease and peripheral vascular disease. CRP is synthesized in the liver and is normally present as a trace constituent of serum or plasma. In various disease states resulting in tissue injury, infection or inflammation, CRP values may rise above normal to 2 to 50 mg/dL within four to eight hours after an acute event. CRP provides useful information for the diagnosis, therapy, and monitoring of inflammatory diseases. Increases in CRP values are non-specific and should not be interpreted without complete clinical history.

Lab Testing Sections:

Chemistry

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

4 hours

Special Instructions:

N/A

Specimen

Specimen Type:

Blood

Container:

Green top (Li Heparin) tube preferred
Alternate tube: Red, marble or gold top tube

Draw Volume:

0.6 mL blood

Processed Volume:

0.2 mL serum/plasma

Collection:

Routine venipuncture. Mix tubes containing anticoagulant by gentle inversion.

Special Processing:

Lab Staff: Centrifuge specimen, remove serum/plasma aliquot into a plastic sample cup. Store at 20 – 25 degrees Centigrade for up to 8 hours, or 2 – 8 degrees Centigrade for up to 3 days.

Patient Preparation:

None

Sample Rejection:

Mislabeled or unlabeled specimen

Interpretive

Reference Range:

0 – 0.3 mg/dL

Critical Values:

N/A

Limitations:

This assay is not intended to assess cardiovascular risk.

Methodology:

Nephelometry, Siemens Dimension Vista

References:

Jacobs & DeMott Laboratory Test Handbook (2001) Lexi-Comp, Inc, Hudson, OH, 5th Edition

Bio-Rad Liquichek Lipids Control Product Insert, Bio-Rad Laboratories, Irvine, CA 92618

Siemens Dimension Vista CRP Reagent Flex Directions For Use (3/2011), Siemens Healthcare Diagnostics

Updates:

7/14/2014: Method update
2/8/2016: Update alt tube types



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