Clinics and Departments

Laboratory Services

Lab Dept:

Serology

Test Name:

ANTITHYROGLOBULIN ANTIBODY

General Information

Lab Order Codes:

ATA

Synonyms:

Thyroglobulin Antibody

CPT Codes:

86800 – Thyroglobulin antibody

Test Includes:

Thyroglobulin antibody reported in IU/mL.

Logistics

Test Indications:

Primary use: Identification of potentially unreliable serum Tg measurements in the follow-up of patients with differentiated follicular-cell derived thyroid carcinomas.

Secondary use: As an adjunct to anti-thyrotropin and thryoid-stimulating immunoglobulin measurements in the diagnosis of autoimmune thryoid disease: Hashimoto disease, Postpartum thyroiditis, Neonatal hypothyroidism, Graves disease

Lab Testing Sections:

Serology - Sendouts

Referred to:

Mayo Medical Laboratories (MML Test: TGAB)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

1 – 3 days, performed Monday - Saturday

Special Instructions:

If Thyroglobulin Tumor Marker, Serum, is desired, DO NOT order this test. See Thyroglobulin Tumor Marker which includes both thyroglobulin and thyroglobulin antibody. Red No Gel tube required. See Patient Preparation

Specimen

Specimen Type:

Blood

Container:

Red top (no gel) tube

Draw Volume:

1.8 mL (Minimum: 1.5 mL) blood

Processed Volume:

0.6 mL (Minimum: 0.5 mL) serum

Note: Submission of the minimum volume will not allow for repeat analysis and could result in a QNS (quantity not sufficient) result.

Collection:

Routine venipuncture

Special Processing:

Lab Staff: Centrifuge specimen, remove serum aliquot into a screw-capped round bottom plastic vial. Store and ship at refrigerated temperatures. Forward promptly.

Patient Preparation:

Twelve hours before this test, do not take multivitamins or dietary supplements containing biotin or vitamin B7.

Sample Rejection:

Gross hemolysis; mislabeled or unlabeled specimens; specimens collected in gel tubes

Interpretive

Reference Range:

All ages:

<4.0 IU/mL

Critical Values:

N/A

Limitations:

Antithyroglobulin and antithyroid peroxidase values determined by different methodologies might vary significantly and cannot be directly compared with one another. Some patients might show to be antibody-positive by some methods and antibody-negative by others. Comparing anti-Tg and anti-TPO antibody values from different methods might lead to erroneous clinical interpretation.

Methodology:

Immunoenzymatic Assay

References:

Mayo Medical Laboratories April 2016

Updates:

2/11/2008: Reference range update, previously listed as <1:100
Method update: Previously listed as Gelatin Particle Agglutination
5/3/2010: Updated specimen volumes
1/272011: Due to reagent issues at MML, they are now forwarding this testing to Quest. Note the new reference range, change in preferred draw volume and store/ship temperature.
2/3/2011: Back to refrigerated.
4/12/2011: Testing returned to Mayo. New method, new reference range (previously listed as <20 IU/mL).
10/6/2014: New method and reference range. Range previously listed as <116 IU/mL.
4/6/15: Draw volume update.



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