Clinics and Departments

Laboratory Services

Lab Dept:

Urine/Stool

Test Name:

HYPEROXALURIA PANEL, URINE

General Information

Lab Order Codes:

UHPU

Synonyms:

N/A

CPT Codes:

82542 – Column chromatography/mass spectrophotometry; non-drug analytes, not elsewhere specified, qualitative or quantitative, each specimen

Test Includes:

Glycolate, glycorate, oxalate, and 4-Hydroxy-2-Oxoglutarate (HOG) levels reported in mg/g creatinine.

Logistics

Test Indications:

Useful for distinguishing between primary and secondary hyperoxaluria; distinguishing between Type I and Type II primary hyperoxaluria.

Lab Testing Sections:

Urine/Stool - Sendouts

Referred to:

Mayo Medical Laboratories (MML Test: HYOX)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

Varies, batched twice monthly

Special Instructions:

See Patient Preparation:

Specimen

Specimen Type:

Urine, See Patient Preparation:

Container:

Plastic leak-proof urine container (no preservative)

Draw Volume:

Entire Random urine collection

Processed Volume:

10 mL (Absolute minimum: 1.1 mL) random urine

Collection:

Routine random urine collection

Special Processing:

Lab Staff: Remove urine aliquot from a well-mixed specimen. Place aliquot into a 10 mL urine tube. Freeze immediately. Store and ship at frozen temperatures. Forward promptly.

Patient Preparation:

Fasting overnight (12-14 hours, recommended). Have patient void the first-morning specimen, then collect specimen within 2 hours of the first-morning void while the patient continues to fast. Fluids are allowed.

Sample Rejection:

Specimens other than urine; mislabeled or unlabeled specimens

Interpretive

Reference Range:

Analyte

Age

Range (mg/g creatinine)

Glycolate

0 – 1 month

0 - 60

2 – 6 months

0 - 75

7 – 12 months

0 - 75

13 months –
6 years

0 - 75

7 – 10 years

0 - 75

>10 years

0 - 50

Glycerate

0 – 1 month

0 - 75

2 – 6 months

0 - 125

7 – 12 months

0 - 125

13 months –
6 years

0 - 55

7 – 10 years

0 - 55

>10 years

0 - 25

Oxalate

0 – 1 month

0 - 400

2 – 6 months

0 - 400

7 – 12 months

0 - 300

13 months –
6 years

0 - 150

7 – 10 years

0 - 100

>10 years

0 - 75

4-Hydroxy-2-Oxoglutarate (HOG)

0 – 1 month

0 – 15

2 – 6 months

0 – 10

7 – 12 months

0 – 5

13 months –
6 years

0 – 5

7 – 10 years

0 - 5

>10 years

0 – 5

Interpretation:

Increased concentrations of oxalate and glycolate indicate Type I hyperoxaluria.

Increased concentrations of oxalate and glycerate indicate Type II hyperoxaluria.

Increased concentrations of oxalate with normal concentrations of glycolate and glycerate indicate secondary hyperoxaluria.

Critical Values:

N/A

Limitations:

Ascorbic acid will falsely elevate oxalic acid results.

Methodology:

Gas chromatography – Mass spectrometry (GC-MS)

References:

Mayo Medical Laboratories January 2016



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