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Cisplatin (Platinol, CDPP)

Article Translations: (Spanish)

How does this medicine work?

Cisplatin (sis-pla-tin) is a chemotherapy medicine that destroys cancer cells in all phases of cell life.

How is the medicine given?

Cisplatin is given into the vein (IV) by slow infusion in the hospital. It is given with a large amount of IV fluids and a medicine called mannitol to increase urination and help prevent kidney damage.

What are the side effects?


  • low blood cell counts


  • severe nausea and vomiting (this can last several days after chemo is given)


  • kidney damage
  • abnormal magnesium, potassium, and sodium levels in the body
  • hearing loss
  • metal taste in mouth


  • tingling and weakness in hands and feet
  • liver damage
  • ringing in the ears

When should I call the doctor?

  • fever, chills
  • coughing
  • sore throat
  • bleeding, unusual bruising
  • tingling or weakness in the hands or feet
  • continued vomiting
  • seizures
  • dark urine or yellow skin or eyes
  • signs of an allergic reaction:
    • sudden rash, hives
    • itching
    • wheezing
    • trouble breathing - call 911

What else do I need to know?

Give anti-nausea medicines as prescribed for delayed nausea and vomiting after you return home.

The kidney function will be monitored during therapy. This may involve a 12 to 24 hour urine collection. Hearing tests will be done throughout treatment to watch for hearing loss.

All caregivers should wear gloves when handling urine, stool, and vomit while your child is receiving the chemotherapy and for 48 hours afterward. Urine, stool, and vomit can be safely disposed of in septic tanks and the sewer system.

Any clothing or bed linens that are contaminated with urine, stool, or vomit should be washed separately from other laundry in hot water and detergent. Anyone handling the contaminated laundry should wear gloves.

Blood samples may be needed to check the effects of the cisplatin. Blood counts are lowest 2 to 4 weeks after the medicine is given.

You and your child should know the names of all the medicines he or she is taking. Share this information with anyone involved in your child's care.


This is not specific to your child, but provides general information. If you have any questions, please call the oncology clinic or pharmacy.

Last reviewed 8/2015 

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This page is not specific to your child, but provides general information on the topic above. If you have any questions, please call your clinic. For more reading material about this and other health topics, please call or visit Children's Minnesota Family Resource Center library, or visit

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