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Vinorelbine (Navelbine)

How does this medicine work?

Vinorelbine (vin-o-rel-been) is used to destroy cancer cells by interfering with a specific phase of cell life.

How is it given?

Vinorelbine is given by slow IV push in the hospital or clinic.

What are the side effects?


  • pain at the IV site
  • constipation
  • nausea
  • vomiting
  • low blood counts
  • fatigue


  • muscle weakness
  • diarrhea
  • tingling in hands and feet
  • abdominal pain
  • loss of hair


  • fever
  • back pain
  • shortness of breath
  • pancreatitis

Tissue burn may occur if the medicine leaks out of the vein or implanted port.

When should I call the doctor?

  • fever higher than 101.5° F (38.4° C)
  • chills
  • bleeding or bruising
  • tingling or weakness of hands or feet
  • jaw pain
  • continued diarrhea or vomiting
  • no bowel movement for 2 days or more
  • signs of allergic reaction:
    • rash or hives
    • wheezing
    • trouble breathing - call 911

What else do I need to know?

All caregivers should wear gloves when handling urine, stool, and vomit while your child is receiving the chemotherapy and for 48 hours afterward. Urine, stool, and vomit can be safely disposed of in septic tanks and the sewer system.

Any clothing or bed linens that are contaminated with urine, stool, or vomit should be washed separately from other laundry in hot water and detergent. Anyone handling the contaminated laundry should wear gloves.

Most neurological effects (such as jaw pain, tingling, and muscle weakness) are reversible after stopping or decreasing the dose of the medication. A physical therapist may work with you and your child on an exercise program to retain strength and prompt nerve recovery.

You and your child should know the names and doses of all the medicines he or she is taking. Share this information with anyone involved in your child's care.


This sheet is not specific to your child but provides general information. If you have any questions, please call the oncology clinic or pharmacist.

Children's Hospitals and Clinics of Minnesota
Patient/Family Education
2525 Chicago Avenue South
Minneapolis, MN 55404
Last reviewed 8/2015 ©Copyright

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This page is not specific to your child, but provides general information on the topic above. If you have any questions, please call your clinic. For more reading material about this and other health topics, please call or visit Children's Minnesota Family Resource Center library, or visit

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