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Temsirolimus (Torisel)

How does this medicine work?

Temsirolimus (tem-suh-role-uh-muss) is a targeted cancer therapy medication. It works by blocking a protein in cells which normally promotes cell growth and division. Blocking this protein will stop the growth of cancer cells.

How is the medicine given?

Temsirolimus is given into a vein (IV) as an infusion.

What are the side effects?


  • Low blood cell counts
  • Mucositis
  • Weight loss
  • Nausea/vomiting
  • Diarrhea
  • Skin rash
  • Fatigue


  • Allergic reaction
  • Hearing loss
  • Constipation
  • Liver and kidney changes
  • High blood sugar
  • Nose bleed
  • Insomnia
  • Pain
  • Itching
  • Fever, chills
  • Weight loss
  • Headache
  • Cough, shortness of breath
  • Problems with wound healing


  • Blood clots
  • Acute kidney failure
  • Gastrointestinal changes

When should I call the clinic?

Call the clinic if:

  • fever, chills
  • bleeding, unusual bruising
  • cough, shortness of breath, sore throat
  • Signs of an allergic reaction:
    • rash or hives
    • wheezing
    • trouble breathing - call 911

What else do I need to know?

You will receive an antihistamine (such as Benadryl) before the IV infusion. This medication may help prevent an allergic reaction.

Eating grapefruit or drinking grapefruit juice is not allowed for the duration of treatment with Temsirolimus.

Certain medications can increase the side effects or change the activity of Temsirolimus. Please talk with your child’s provider before starting any new medications or supplements.

You will have regular blood tests while receiving this medication. This is to make sure your all your organs are working properly.

All caregivers should wear gloves when handling urine, stool, and vomit while your child is receiving chemotherapy and for 48 hours afterward. Urine, stool, and vomit can be safely disposed of in septic tanks and the sewer system.

Any clothes or bed linens that are contaminated with urine, stool, or vomit should be washed separately from other laundry in hot water and detergent. Anyone handling the contaminated laundry should wear gloves.


This sheet is not specific to your child but provides general information. If you have any questions, please call the oncology clinic or pharmacy.

Patient/Family Education
2525 Chicago Avenue South
Minneapolis, MN 55404

Last reviewed Hem/Onc 6/2015 ©Copyright

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This page is not specific to your child, but provides general information on the topic above. If you have any questions, please call your clinic. For more reading material about this and other health topics, please call or visit Children's Minnesota Family Resource Center library, or visit

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