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FPIES Oral Food Challenge Information

Your child is scheduled for an Oral Food Challenge (OFC). This is an exciting step in your child’s allergy journey.

Before the OFC: How to prepare 

Bring the food being challenged in the purest form available. The food must not have any of your child’s other allergens (if any).

Do not give your child anything other than clear liquids (clear juice or water) for 4 hours before the oral food challenge time.

The day of the OFC: What to expect

Your child will be seen by an advanced practice nurse (nurse practitioner) to make sure your child is well enough to do the the OFC. You will have a chance to ask questions. Your child will change into a hospital gown and an IV will be started.

During the OFC, your child will get 1 dose of the food based on weight. A nurse will check your child’s skin and vital signs (temperature, blood pressure, heart rate and respirations) often. After the dose is given, your child will be monitored for at least 4-6 hours.

If there are signs or symptoms of a reaction, medicine may be given depending on the severity of the reaction.

A reaction may include, but is not limited to:

  • abdominal pain
  • vomiting
  • diarrhea
  • hypotension (low blood pressure)

If medicine is given, your child will be monitored longer.

After the OFC: Care at home

After leaving the hospital, watch for signs or symptoms of a reaction.

The advanced practice nurse will give your allergist an update on your child.

Avoid the allergen tested until your allergist gives you instructions on how to bring this new food into your child’s diet. 


This sheet is not specific to your child but provides general information. If you have any questions, please call your clinic.

Last reviewed 5/2016

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This page is not specific to your child, but provides general information on the topic above. If you have any questions, please call your clinic. For more reading material about this and other health topics, please call or visit Children's Family Resource Center library, or visit

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