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Ganitumab (AMG 479)

How does this medicine work?

Ganitumab is a cancer medicine known as a monoclonal antibody. It works by attaching to cancer cells and blocking signals important for cell growth.

How is the medicine given?

Ganitumab is given by IV and should be protected from light. After the infusion finishes you will be monitored by staff for one hour.

What are the side effects?


  • Fever
  • Chills
  • Rash
  • Low blood pressure
  • Abnormal blood sugar
  • Tiredness


  • Low blood counts
  • Bleeding
  • Diarrhea
  • Liver changes
  • Vomiting


  • Hearing loss
  • Difficulty breathing
  • Liver and/or kidney changes

When should I call the clinic?

Call the clinic if:

  • Fever, chills
  • Bleeding, unusual bruising
  • Arm or leg swelling
  • Cough, shortness of breath, sore throat
  • Signs of an allergic reaction:

            - rash or hives

            - wheezing

            - trouble breathing - call 911

What else do I need to know?

This medication is not approved by the FDA. You or your child are taking this medication as part of an investigational study.

 If you are sexually active, pregnant, could become pregnant, or are breastfeeding, DO NOT take or administer Ganitumab without checking with your health care provider first.

You or your child will have regular blood tests while receiving this medication. This is to make sure all of the body’s organs are working properly.

You and your child should know the names of all the medicines he or she is taking. Share this information with anyone involved in your child’s care.

If too much OR the wrong medicine is taken, call the oncology clinic right away. If your child is unconscious or has a seizure, call 911.


This sheet is not specific to your child but provides general information. If you have any questions, please call the oncology clinic or pharmacy.

Reviewed by Hem/Onc 12/2016

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This page is not specific to your child, but provides general information on the topic above. If you have any questions, please call your clinic. For more reading material about this and other health topics, please call or visit Children's Minnesota Family Resource Center library, or visit

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