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Glembatumumab Vedotin (CDX-011)

What is Glembatumumab Vedotin?

Glembatumumab Vedotin is a cancer medicine known as a monoclonal antibody drug combination. It works by using the body’s immune system to deliver cancer medicine to destroy or stop the growth of cancer cells.

How is the medicine given?

Glembatumumab Vedotin is given as an infusion into a vein (IV) in the hospital or clinic.

What are the side effects?

Common

  • Diarrhea, nausea
  • Loss of appetite
  • Hair Loss
  • Itching, rash
  • Tiredness

Occasional

  • Low blood counts
  • Pain
  • Sores in the mouth
  • Muscle weakness, numbness
  • Vomiting, heartburn
  • Increased sweating
  • Shortness of breath
  • Redness, pain or peeling of hands and feet
  • Change or loss of finger/toe nails
  • Muscle/joint pain

Rare

  • Swelling or redness at IV site
  • Blood clot

 

When should I call the clinic?

Call the clinic if:

  • Fever, bleeding, unusual bruising
  • Arm or leg swelling
  • Cough, shortness of breath, sore throat
  • Signs of an allergic reaction:

      - rash or hives

      - wheezing

      - trouble breathing - call 911

What else do I need to know?

This drug is not approved by the FDA. You or your child are taking this medication as a part of an investigational study.

If you are pregnant, could become pregnant, or are breastfeeding, DO NOT take or administer Glembatumumab Vedotin without checking with your health care provider first.

You or your child will have regular blood tests while receiving this medication. This is to make sure all of the body’s organs are working properly.

You and your child should know the names of all the medicines he or she is taking. Share this information with anyone involved in your child’s care.

If too much OR the wrong medicine is taken, call the oncology clinic right away. If your child is unconscious or has a seizure, call 911.

Questions?

This information is not specific to your child but provides general information. If you have any questions, please call your clinic.

Reviewed by Hem/Onc 12/2016

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This page is not specific to your child, but provides general information on the topic above. If you have any questions, please call your clinic. For more reading material about this and other health topics, please call or visit Children's Family Resource Center library, or visit www.childrensmn.org/educationmaterials.

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