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Lorvotuzumab (IMGN901)

How does this medicine work?

Lorvotuzumab (Lorv-oh-too-zoo-mab) is a cancer medicine known as a monoclonal antibody. It works by using the body’s immune system to deliver cancer medicine to destroy or stop the growth of cancer cells.

How is the medicine given?

Lorvotuzumab is given by IV and should be protected from light. After the infusion finishes you will be monitored by staff for an hour.

What are the side effects?


  • Tiredness Headache
  • Nausea
  • Tingling, numbness or pain in hands or feet
  • Low blood counts


  • Vomiting
  • Chills
  • Muscle/Joint pain
  • Constipation
  • Increased blood sugar


  • Vision loss
  • Liver and/or kidney changes
  • Bleeding
  • Seizure
  • Reaction to infusion: Fever, chills, low blood pressure

When should I call the clinic?

Call the clinic if:

  • Fever, chills
  • Bleeding, unusual bruising
  • Arm or leg swelling
  • Cough, shortness of breath, sore throat
  • Signs of an allergic reaction:

            - rash or hives

            - wheezing

            - trouble breathing - call 911

What else do I need to know?

This medication is not approved by the FDA. You are receiving this medication as part of an investigational study.

If you are pregnant, could become pregnant, or are breast-feeding, DO NOT take or administer Lorvotuzumab without checking with your health care provider first.

You and your child should know the names of all the medicines he or she is taking. Share this information with anyone involved in your child’s care.


This is not specific to your child but provides general information. If you have any questions, please call the oncology clinic or pharmacy.

Reviewed by Hem/Onc 12/2016

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This page is not specific to your child, but provides general information on the topic above. If you have any questions, please call your clinic. For more reading material about this and other health topics, please call or visit Children's Minnesota Family Resource Center library, or visit

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