What do I need to know after my child has a blood transfusion?

Transfusion of blood and blood products is usually a safe and effective way to correct blood problems. Most transfusions are tolerated well, but some children may have a transfusion reaction.

Most transfusion reactions occur within minutes after starting the transfusion. It is rare, but some signs of a transfusion reaction may not appear until hours or days (usually within 7 to 10 days) after the transfusion. Most signs of a transfusion reaction will be mild, but you should take your child's temperature and call the doctor if any occur.

When should I call the doctor?

Call the provider if your child experiences any of the following:

• chills
• temperature 2° F or more degrees higher than at the time of the transfusion
• fever 101° F (38.3° C) or higher 
  • If your child is receiving treatment for cancer, please call if their fever is 100.4° F (38° C) or higher that continues for one hour
• swelling or flushing of the face
• hives or skin rash, with or without itching
• persistent cough
• irritability
• restlessness
• headache
• urine is red or unusually dark
• joint pain
• nausea (upset stomach)

Call 911 if:

• breathing problems
• blueness of lips or fingernails
• shortness of breath
• wheezing
• pain in the chest or abdomen (belly)
• very sleepy, difficult to wake
• extreme irritability or restlessness

Questions?

This sheet is not specific to your child but provides general information. If you have any questions, please call the doctor.

Reviewed 12/2024