Lab Dept:


Test Name:


General Information

Lab Order Codes:



Chromium, serum; Cr

CPT Codes:

82495 - Chromium

Test Includes:

Serum chromium result measured in ng/mL.


Test Indications:

Useful for detecting exposure to chromium, monitoring nutritional supplementation levels, clinical trials, monitoring metallic prosthetic implant wear.

Lab Testing Sections:

Chemistry - Sendouts

Referred to:

Mayo Medical Laboratories (Test# 8638/CRS)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

1 - 4 days

Special Instructions:

Obtain special syringe/tube from the laboratory. See Container, Collection


Specimen Type:



Royal Blue top, Trace element tube (Mayo Supply T184)

Draw Volume:

4.8 mL (Minimum: 1.2 mL) blood

Processed Volume:

1.6 mL (Minimum: 0.4 mL) serum


Routine venipuncture


Special Processing:

Lab Staff: Allow specimen to clot in the syringe 30 minutes. To prevent contamination, Do Not ream the specimen with a wooden stick. Centrifuge sample. To prevent contamination Do Not transfer the specimen with a pipette. Pour off serum into a 7 mL Metal-Free screw-capped polypropylene tube. Serum aliquot is stored refrigerated. Forward promptly.

Patient Preparation:


Sample Rejection:

Mislabeled or unlabeled specimens; grossly icteric


Reference Range:

<0.3 ng/mL

When collected by a phlebotomist experienced in ultra clean collection technique and handled according to the instructions, the normal concentration of chromium in serum to be <0.3 ng/mL. However, the majority of specimens submitted for analysis from normal, unexposed individuals contain 0.3 – 0.9 ng/mL of chromium. Commercial evacuated blood collection tubes yield serum containing 2.0 – 5.0 ng/mL chromium.

Critical Values:



Normal specimens have extremely low levels of Cr; therefore, elevated results could easily be a result of external contamination. Precautions must be taken to ensure the specimen is not contaminated. Metal-free serum collection procedures must be followed and centrifuged serum must be aliquoted into an acid washed Mayo metal free vial. Specimens collected using an anticoagulant are unacceptable, due to trace amounts of Cr found in anticoagulants.

High concentrations of gadolinium and iodide are known to interfere with most metals tests. If either gadolinium or iodide-containing contrast media has been administered a specimen can not be collected for 48 hours.


Dynamic Reaction Cell-Inductivity Coupled Plasma-Mass Spectrometry (DRC-ICP-MS)


Mayo Medical Laboratories Web Page January 2013


12/15/05: Method update at MML, previously listed as Graphite Furnace Atomic Absorption Spectrometry.
11/4/2008: Units change from ug/L to ng/mL.