Lab Dept:


Test Name:

Interleukin-2 Receptor

General Information

Lab Order Codes:



IL 2 Receptor, Soluble (CD25)

CPT Codes:

83520 – Immunoassay for analyte other than infectious agent antibody or infectious agent antigen; quantitative, not otherwise specified

Test Includes:

Interleukin-2 Receptor level reported in pg/mL.


Test Indications:

Clinical conditions in which elevated soluble IL-2R levels are detected include AIDS, autoimmune disease, sarcoidosis, and a variety of leukemias and lymphomas. In HIV positive individuals, IL-2R is elevated during the asymptomatic phase as well as during persistent generalized lymphadenopathy and symptomatic phases. IL-2R detection may be useful in measuring T cell activation and monitoring HIV pathogenesis. Elevated IL-2R levels have clinical and prognostic significance in patients with malignant lymphoma, non-Hodgkin’s lymphoma, B cell and undifferentiated lymphomas.

Lab Testing Sections:

Chemistry - Sendouts

Referred to:

Mayo Medical Laboratories forward to ARUP (MML Test: FIL2S), (ARUP Test: 0051529)

Phone Numbers:

MIN Lab: 612-813-6280

STP Lab: 651-220-6550

Test Availability:

Daily, 24 hours

Turnaround Time:

1 - 4 days; set-up Monday, Wednesday and Friday

Special Instructions:



Specimen Type:



Green top (Lithium Heparin) tube
Alternate tubes: Red top tube

Draw Volume:

3 mL (Minimum: 1 mL) blood

Processed Volume:

1 mL (Minimum: 0.3 mL) serum/plasma


Routine venipuncture


Special Processing:

Lab Staff: Centrifuge specimen and separate serum/plasma within 2 hours of collection; aliquot into a screw-capped round bottom plastic vial. Store and ship at frozen temperatures. Forward promptly.

Patient Preparation:


Sample Rejection:

Mislabeled or unlabeled specimens; refrigerated specimens; contaminated or heat-inactivated specimens


Reference Range:

< or =1032 pg/mL

Critical Values:



Results are to be used for research purposes or in attempts to understand the pathophysiology of immune, infectious or inflammatory conditions.


Quantitative Multiplex Bead Assay


Mayo Medical Laboratories Web Page February 2014

ARUP Laboratories February 2014


3/18/2004: Test moved from Specialty Laboratories to Mayo Medical Laboratories forward to Focus Technologies. Note changes in CPT code, Methodology, and reference range.
9/16/2008: CPT update, previously reported at 83520
12/16/2013: MML now forwards to ARUP. Note change in CPT (previously 84238), method and reference ranges.
2/19/2014: Ref range update, previously listed as 0-1033 pg/mL.